In art history, the High Renaissance was a short period of the most exceptional artistic production in the Italian states, particularly Rome, capital of the Papal States, and in Florence, during the Italian Renaissance. Most art historians state that the High Renaissance started between 1490 and 1500, and ended in 1520 with the death of Raphael, although some say the High Renaissance ended about 1525, or in 1527 with the Sack of Rome by the mutinous army of Charles V, Holy Roman Emperor, or about 1530. The best-known exponents of painting, sculpture and architecture of the High Renaissance include Leonardo da Vinci, Michelangelo, Raphael, and Bramante. In the 21st century, the use of the term has been frequently criticized by some academic art historians for oversimplifying artistic developments, ignoring historical context, and focusing only on a few iconic works.

The Sack of Rome, then part of the Papal States, followed the capture of the city on 6 May 1527 by the mutinous troops of Charles V, Holy Roman Emperor, during his war with the League of Cognac, known as the War of the League of Cognac. Despite being ordered not to storm the city, with Charles V intending to only use the threat of military action to make Pope Clement VII come to his terms, a largely unpaid Imperial army formed by 14,000 Germans, many of them Lutheran, 6,000 Spaniards and some Italian contingents occupied the scarcely defended Rome and began looting, slaying and holding citizens for ransom in excess without any restraint. Clement VII took refuge in Castel Sant'Angelo after the Swiss Guard were annihilated in a delaying rearguard action; he remained there until a ransom was paid to the pillagers.