Highspire is a borough in Dauphin County, Pennsylvania, United States. The population was 2,741 at the 2020 census, an increase over the figure of 2,399 tabulated in 2010. It is part of the Harrisburg–Carlisle Metropolitan Statistical Area.

Dauphin County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 286,401. The county seat is Harrisburg, Pennsylvania's state capital and ninth-most populous city. The county was created on March 4, 1785, from part of Lancaster County and was named after Louis Joseph, Dauphin of France, the first son of King Louis XVI. The county is part of the South Central Pennsylvania region of the state.