The Highway of Tears is a 719-kilometre (447 mi) corridor of Highway 16 between Prince George and Prince Rupert in British Columbia, Canada, which has been the location of crimes against many Missing and Murdered Indigenous Women (MMIW) beginning in 1970. The phrase was coined during a vigil held in Terrace, British Columbia in 1998, by Florence Naziel, who was thinking of the victims' families crying over their loved ones. There are a disproportionately high number of Indigenous women on the list of victims.

Highway 16 is a highway in British Columbia, Canada. It is an important section of the Yellowhead Highway, a part of the Trans-Canada Highway that runs across Western Canada. The highway closely follows the path of the northern B.C. alignment of the Canadian National Railway (CN). The number "16" was first given to the highway in 1941, and originally, the route that the highway took was more to the north of today's highway, and it was not as long as it is now. Highway 16 originally ran from New Hazelton east to Aleza Lake. In 1947, Highway 16's western end was moved from New Hazelton to the coastal city of Prince Rupert, and in 1953, the highway was re-aligned to end at Prince George. In 1969, further alignment east into Yellowhead Pass was opened to traffic after being constructed up through 1968 and raised to all-weather standards in 1969. Highway 16's alignment on Haida Gwaii was commissioned in 1983 and is connected to the mainland segment via BC Ferries route #11.