Hillsboro is a town in Lawrence County, Alabama, and is included in the Decatur Metropolitan Area, as well as the Huntsville-Decatur Combined Statistical Area. It was incorporated in 1899. As of the 2010 census, the population of the town is 552, down from its record high of 608 in 2000. Along with North Courtland, it is one of two majority black communities in Lawrence County out of its six populated communities as of 2010.

Lawrence County is a county in the northern part of the U.S. state of Alabama. As of the 2020 census, the population was 33,073. The county seat is Moulton. The county was named after James Lawrence, a captain in the United States Navy from New Jersey.