Hillsborough High School is a public high school located at 5000 N. Central Ave, in the heart of the historic Seminole Heights neighborhood, in Tampa, Florida. Hillsborough High is the oldest public high school in Hillsborough County, Florida.

Seminole Heights is a historic neighborhood and district located in central Tampa. It is bounded on the west by Florida Avenue, on the north by Hanna Avenue, on the east by Interstate 275 and on the south by Osborne Avenue. It includes many early 20th century bungalow homes and historic buildings. It was an early residential area of Tampa connected by streetcar. The area had an economic downturn in the late 20th century marked by increased crime, but has since seen a resurgence with new restaurants, brew pubs and independent businesses opening up. The neighborhood's historic homes, eclectic shops and gourmet restaurants are an increasing draw.