The Hilton Head Island metropolitan area, officially the Hilton Head Island–Bluffton–Port Royal, SC Metropolitan Statistical Area as defined by the United States Census Bureau, is a metropolitan statistical area consisting of the two southernmost counties in the Lowcountry region of South Carolina, centered on the resort town of Hilton Head Island. As of the 2020 census, the MSA had a population of 215,908. Prior to March 2013, the region was considered a micropolitan statistical area.

Hilton Head Island, often referred to as simply Hilton Head, is a Lowcountry resort town and barrier island in Beaufort County, South Carolina, United States. It is 20 miles (32 km) northeast of Savannah, Georgia, and 95 miles (153 km) southwest of Charleston. The island is named after Captain William Hilton, who in 1663 identified a headland near the entrance to Port Royal Sound, which mapmakers named "Hilton's Headland." The island features 12 miles (19 km) of beachfront on the Atlantic Ocean and is a popular vacation destination. In 2004, an estimated 2.25 million visitors infused more than $1.5 billion into the local economy. The year-round population was 37,661 at the 2020 census, although during the peak of summer vacation season the population can swell to 150,000. Hilton Head Island is the largest city within the Hilton Head Island-Bluffton-Port Royal, SC Metropolitan Statistical Area, which had an estimated population of 232,523 in 2023.