The history of African Americans in Baltimore dates back to the 17th century when the first African slaves were being brought to the Province of Maryland. Majority white for most of its history, Baltimore transitioned to having a black majority in the 1970s. As of the 2010 Census, African Americans are the majority population of Baltimore at 63% of the population. As a majority black city for the last several decades with the 5th largest population of African Americans of any city in the United States, African Americans have had an enormous impact on the culture, dialect, history, politics, and music of the city. Unlike many other Northern cities whose African-American populations first became well-established during the Great Migration, Baltimore has a deeply rooted African-American heritage, being home to the largest population of free black people half a century before the Emancipation Proclamation. The migrations of Southern and Appalachian African Americans between 1910 and 1970 brought thousands of African Americans to Baltimore, transforming the city into the second northernmost majority-black city in the United States after Detroit. The city's African-American community is centered in West Baltimore and East Baltimore. The distribution of African Americans on both the West and the East sides of Baltimore is sometimes called "The Black Butterfly", while the distribution of white Americans in Central and Southeast Baltimore is called "The White L."

The Great Migration, sometimes known as the Great Northward Migration or the Black Migration, was the movement of six million African Americans out of the rural Southern United States to the urban Northeast, Midwest, and West between 1910 and 1970. It was substantially caused by poor economic and social conditions due to prevalent racial segregation and discrimination in the Southern states where Jim Crow laws were upheld. In particular, continued lynchings motivated a portion of the migrants, as African Americans searched for social reprieve. The historic change brought by the migration was amplified because the migrants, for the most part, moved to the then-largest cities in the United States at a time when those cities had a central cultural, social, political, and economic influence over the United States; there, African-Americans established culturally influential communities of their own. According to Isabel Wilkerson, despite the loss of leaving their homes in the South, and the barriers faced by the migrants in their new homes, the migration was an act of individual and collective agency, which changed the course of American history, a "declaration of independence" written by their actions.