Honduras was inhabited by many indigenous peoples when the Spanish arrived in the 16th century. The western-central part of Honduras was inhabited by the Lencas, the central north coast by the Tol, the area east and west of Trujillo by the Pech, the Maya and Sumo. These autonomous groups traded with each other and with other populations as distant as Panama and Mexico. Honduras has ruins of several cities dating from the Mesoamerican pre-classic period that show the pre-Columbian past of the country.

Trujillo is a city, with a population of 22,750, and a municipality on the northern Caribbean coast of the Honduran department of Colón, of which the city is the capital.