The history of Islam in Sicily and southern Italy began with the first Arab settlement in Sicily, at Mazara, which was captured in 827. The subsequent rule of Sicily and Malta started in the 10th century. The Emirate of Sicily lasted from 831 until 1061, and controlled the whole island by 902. Though Sicily was the primary Muslim stronghold in Italy, some temporary footholds, the most substantial of which was the port city of Bari, were established on the mainland peninsula, especially in mainland southern Italy, though Muslim raids, mainly those of Muhammad I ibn al-Aghlab, reached as far north as Naples, Rome and the northern region of Piedmont. The Arab raids were part of a larger struggle for power in Italy and Europe, with Christian Byzantine, Frankish, Norman and local Italian forces also competing for control. Arabs were sometimes sought as allies by various Christian factions against other factions.

Southern Italy, also known as Meridione or Mezzogiorno, is a macroregion of Italy consisting of its southern regions.