The recorded history of the Dominican Republic began in 1492 when the Genoa-born navigator Christopher Columbus, working for the Crown of Castile, happened upon a large island in the region of the western Atlantic Ocean that later came to be known as the Caribbean. It was inhabited by the Taíno, an Arawakan people, who called the eastern part of the island Quisqueya (Kiskeya), meaning "mother of all lands." Columbus promptly claimed the island for the Spanish Crown, naming it La Isla Española, later Latinized to Hispaniola. After 25 years of Spanish occupation, the Taíno population in the Spanish-dominated parts of the island drastically decreased through genocide. With fewer than 50,000 remaining, the survivors intermixed with Spaniards, Africans, and others, forming the present-day tripartite Dominican population. What would become the Dominican Republic was the Spanish Captaincy General of Santo Domingo until 1821, except for a time as a French colony from 1795 to 1809. It was then part of a unified Hispaniola with Haiti from 1822 until 1844. In 1844, Dominican independence was proclaimed and the republic, which was often known as Santo Domingo until the early 20th century, maintained its independence except for a short Spanish occupation from 1861 to 1865 and occupation by the United States from 1916 to 1924.

The Captaincy General of Santo Domingo was the first Capitancy in the New World, established by Spain in 1492 on the island of Hispaniola. The Capitancy, under the jurisdiction of the Real Audiencia of Santo Domingo, was granted administrative powers over the Spanish possessions in the Caribbean and most of its mainland coasts, making Santo Domingo the principal political entity of the early colonial period.