The history of the Jews in Argentina goes back to the early sixteenth century, following the Jewish expulsion from Spain. Sephardi Jews fleeing persecution immigrated with explorers and colonists to settle in what is now Argentina, in spite of being forbidden from travelling to the American colonies. In addition, many of the Portuguese traders in the Viceroyalty of the Río de la Plata were Jewish. An organized Jewish community, however, did not develop until after Argentina gained independence from Spain in 1816. By mid-century, Jews from France and other parts of Western Europe, fleeing the social and economic disruptions of revolutions, began to settle in Argentina.

Moisés Ville is a small town (comuna) in the province of Santa Fe, Argentina, founded on 23 October 1889 by Eastern European and Russian Jews escaping pogroms and persecution. The original name intended for the town was Kiryat Moshe honoring Baron Maurice Moshe Hirsch, but the land agent who registered the settlement translated it to the French-like Moïsesville which was later hispanized to the current Moisés Ville. The town is located about 177 km (110 mi) from the provincial capital, in the San Cristóbal Department and 616 km (383 mi) from Buenos Aires. It had 2,425 inhabitants at the 2010 census [INDEC].