Hodonín District is a district in the South Moravian Region of the Czech Republic. Its capital is the town of Hodonín.

The South Moravian Region, or just South Moravia, is an administrative unit of the Czech Republic, located in the south-western part of its historical region of Moravia. The region's capital is Brno, the nation's 2nd largest city. South Moravia is bordered by the South Bohemian Region to the west, Vysočina Region to the north-west, Pardubice Region to the north, Olomouc Region to the north-east, Zlín Region to the east, Trenčín and Trnava Regions, Slovakia to the south-east and Lower Austria, Austria to the south.