Holguín is a municipality-city in Cuba. After Havana, Santiago de Cuba, and Camagüey, it is the fourth largest city in Cuba.

Pope Francis visited North America—Cuba and the United States—from 19 to 27 September 2015. It was his first state visit to both Cuba and the U.S., as well as the third official papal visit to Cuba and the seventh to the United States since the U.S. established full diplomatic relations with the Holy See in 1984.