Holme-on-Spalding-Moor is a large village and civil parish in the East Riding of Yorkshire, England. It is situated approximately 7 miles (11 km) north-east of Howden and 5 miles (8 km) south-west of Market Weighton. It lies on the A163 road where it joins the A614 road.

The East Riding of Yorkshire, often abbreviated to the East Riding or East Yorkshire, is a ceremonial county in the Yorkshire and the Humber region of England. It borders North Yorkshire to the north and west, South Yorkshire to the south-west, and Lincolnshire to the south across the Humber Estuary. The city of Kingston upon Hull is the largest settlement.