Holmes County is a county in the U.S. state of Mississippi; its western border is formed by the Yazoo River and the eastern border by the Big Black River. The western part of the county is within the Yazoo-Mississippi Delta. As of the 2020 census, the population was 17,000. Its county seat is Lexington. The county is named in honor of David Holmes, territorial governor and the first governor of the state of Mississippi and later United States Senator for Mississippi. Holmes County native, Edmond Favor Noel, was an attorney and state politician, elected as governor of Mississippi, serving from 1908 to 1912.

The Yazoo River is a river in the U.S. states of Louisiana and Mississippi. It is considered by some to mark the southern boundary of what is called the Mississippi Delta, a broad floodplain that was cultivated for cotton plantations before the American Civil War. It has continued to be devoted to large-scale agriculture.