Holt County is a county located in the northwestern portion of the U.S. state of Missouri. As of the 2020 census, the population was 4,223. It's county seat is Oregon. The county was organized February 15, 1841. Originally named Nodaway County, it was soon renamed for David Rice Holt (1803–1840), a Missouri state legislator from Platte County.

Oregon is a city and county seat of Holt County, Missouri, United States. The population was 837 at the 2020 census.