Holtville is a city in Imperial County, California. Holtville is located 10.5 miles (17 km) east of El Centro. The population was 5,939 at the 2010 census, up from 5,612 in 2000.

State Route 7 is a state highway in the U.S. state of California, running from the Calexico East Port of Entry on the U.S.-Mexico border east of Calexico north to its terminus at Interstate 8 (I-8), where Orchard Road continues the route north towards Holtville. The route provides convenient access to the country of Mexico from I-8. The southern portion of the route opened in 1996, and the rest of the route connecting to I-8 opened in 2005.