The Holy Prepuce, or Holy Foreskin, is one of several relics attributed to Jesus, consisting of the foreskin removed during the circumcision of Jesus. At various points in history, a number of churches in Europe have claimed to possess the Prepuce, sometimes at the same time. Various miraculous powers have been ascribed to it.

A number of alleged relics associated with Jesus have been displayed throughout the history of Christianity. While some individuals believe in the authenticity of Jesus relics, others doubt their validity. For instance, the sixteenth-century philosopher Erasmus wrote about the proliferation of relics, and the number of buildings that could be constructed from wooden relics claimed to be from the crucifixion cross of Jesus. Similarly, at least thirty Holy Nails were venerated as relics across Europe in the early 20th century. Part of the relics are included in the so-called Arma Christi, or the Instruments of the Passion.