Holy See–Ireland relations are foreign relations between the Holy See and Ireland. The majority of Irish people identify as Roman Catholic, according to census data. However, views on actual church dogma both on social and spiritual matters varies significantly, and weekly mass attendance is below 40%. The Holy See has an Apostolic Nunciature in Dublin.

Charles John Brown is an American prelate of the Roman Catholic Church who has been serving as an apostolic nuncio since 2012. He is currently the apostolic nuncio to the Philippines. Before entering the diplomatic service of the Holy See, Brown worked at the Congregation for the Doctrine of the Faith (CDF).