Holy Trinity Church in Southport, Merseyside, England, is an Anglican parish church in the diocese of Liverpool and a Grade II* listed building. It was built in the early 20th century, and designed by Huon Matear in free Decorated style. It is constructed mainly in red brick, and has a tower, the upper parts of which are in elaborately decorated stone. Many of the internal furnishings are by the Bromsgrove Guild.

There are over 20,000 Grade II* listed buildings in England. This page is a list of these buildings in the county of Merseyside.