Home on the Prairie is a 1939 American Western film directed by Jack Townley and starring Gene Autry, Smiley Burnette, and June Storey. Written by Charles Arthur Powell and Paul Franklin, the film is about a cattle inspector's efforts to prevent a corrupt cattle rancher from shipping to market a herd of cattle infected with hoof and mouth disease.

Lester Alvin Burnett, better known as Smiley Burnette, was an American country music performer and a comedic actor in Western films and on radio and TV, playing sidekick to Gene Autry, Roy Rogers, and other B-movie cowboys. He was also a prolific singer-songwriter who is reported to have played proficiently over 100 musical instruments, sometimes more than one simultaneously. His career, beginning in 1934, spanned four decades, including a regular role on CBS-TV's Petticoat Junction in the 1960s.