The Homestake Mine was a deep underground gold mine located in Lead, South Dakota. Until it closed in 2002 it was the largest and deepest gold mine in North America. The mine produced more than forty million troy ounces of gold during its lifetime. This is about 2,500 cubic feet (71 m3) or a volume of gold roughly equal to 18,677 US gallons.

Lead is a city in Lawrence County, South Dakota, United States. The population was 2,982 at the 2020 census. Lead is located in western South Dakota, in the Black Hills near the Wyoming state line.