Homotherium is an extinct genus of machairodontine scimitar-toothed cat that inhabited North America, South America, Eurasia, and Africa during the Pliocene and Pleistocene epochs from around 4 million to 12,000 years ago. In comparison to Smilodon, the canines of Homotherium were shorter, and it was probably adapted to running down rather than ambushing prey.

Machairodontinae is an extinct subfamily of carnivoran mammals of the family Felidae. They were found in Asia, Africa, North America, South America, and Europe from the Miocene to the Pleistocene, living from about 16 million until about 10,000 years ago.