Honey Brook is a borough in Chester County, Pennsylvania, United States. The population of the borough was 1,895 at the 2020 census. The borough is surrounded by Honey Brook Township, and both are referred to locally collectively as Honey Brook.

Pennsylvania Route 10 is a 44.04-mile-long (70.88 km) state route in southeastern Pennsylvania. Its southern terminus is at PA 472 in Oxford. Its northern terminus is at U.S. Route 222 Business in Reading. PA 10 is mostly a two-lane undivided road that serves Chester, Lancaster, and Berks counties. The route begins in Oxford and passes through rural areas of western Chester County, serving Cochranville, Parkesburg, Compass, and Honey Brook. The route passes through a small corner of eastern Lancaster County before it enters Berks County and reaches Morgantown, where it has interchanges with Interstate 176 (I-176) and the Pennsylvania Turnpike (I-76). Between Morgantown and Reading, PA 10 parallels I-176.