Honjō Domain was a feudal domain in Edo period Japan, located in Dewa Province, Japan. It was centered on Honjō Castle in what is now the city of Yurihonjō, Akita.

Dewa Province was a province of Japan comprising modern-day Yamagata Prefecture and Akita Prefecture, except for the city of Kazuno and the town of Kosaka. Dewa bordered on Mutsu and Echigō Provinces. Its abbreviated form name was Ushū (羽州).