Horio Yoshiharu was a Japanese daimyō during the Azuchi–Momoyama and Edo periods. He was appointed to the position of one of san-chūrō by Toyotomi Hideyoshi along with Ikoma Chikamasa and Nakamura Kazuuji. He was the first leader of the Matsue clan and also known as Horio Mosuke.

The siege of Inabayama Castle of 1567 was the final battle in Oda Nobunaga's campaign to defeat the Saitō clan in their mountaintop castle and conquer Mino Province, Japan.