Hormizd-Ardashir, better known by his dynastic name of Hormizd I, was the third Sasanian King of Kings (shahanshah) of Iran, who ruled from May 270 to June 271. He was the third-born son of Shapur I, under whom he was governor-king of Armenia, and also took part in his father's wars against the Roman Empire. Hormizd I's brief time as ruler of Iran was largely uneventful. He built the city of Hormizd-Ardashir, which remains a major city today in Iran. He promoted the Zoroastrian priest Kartir to the rank of chief priest (mowbed) and gave the Manichaean prophet Mani permission to continue his preaching.

Shapur I was the second Sasanian King of Kings of Iran. The precise dating of his reign is disputed, but it is generally agreed that he ruled from 240 to 270, with his father Ardashir I as co-regent until the death of the latter in 242. During his co-regency, he helped his father with the conquest and destruction of the city of Hatra, whose fall was facilitated, according to Islamic tradition, by the actions of his future wife al-Nadirah. Shapur also consolidated and expanded the empire of Ardashir I, waged war against the Roman Empire, and seized its cities of Nisibis and Carrhae while he was advancing as far as Roman Syria. Although he was defeated at the Battle of Resaena in 243 by Roman emperor Gordian III, he was the following year able to win the Battle of Misiche and force the new Roman emperor Philip the Arab to sign a favorable peace treaty that was regarded by the Romans as "a most shameful treaty".