Host (biology)

The black rat is a reservoir host for bubonic plague: the oriental rat fleas that infest these rats are vectors for the disease.

In biology and medicine, a host is an organism that harbours a parasitic, a mutualistic, or a commensalist guest (symbiont), the guest typically being provided with nourishment and shelter. Examples include animals playing host to parasitic worms (e.g. nematodes), cells harbouring pathogenic (disease-causing) viruses, a bean plant hosting mutualistic (helpful) nitrogen-fixing bacteria. More specifically in botany, a host plant supplies food resources to micropredators, which have an evolutionarily stable relationship with their hosts similar to ectoparasitism. The host range is the collection of hosts that an organism can use as a partner.

Symbiosis[edit]

Symbiosis spans a wide variety of possible relationships between organisms, differing in their permanence and their effects on the two parties. If one of the partners in an association is much larger than the other, it is generally known as the host.^[1] In parasitism, the parasite benefits at the host's expense.^[2] In commensalism, the two live together without harming each other,^[3] while in mutualism, both parties benefit.^[4]

Most parasites are only parasitic for part of their life cycle. By comparing parasites with their closest free-living relatives, parasitism has been shown to have evolved on at least 233 separate occasions. Some organisms live in close association with a host and only become parasitic when environmental conditions deteriorate.^[5]

A parasite may have a long term relationship with its host, as is the case with all endoparasites. The guest seeks out the host and obtains food or another service from it, but does not usually kill it.^[6] In contrast, a parasitoid spends a large part of its life within or on a single host, ultimately causing the host's death, with some of the strategies involved verging on predation. Generally the host is kept alive until the parasitoid is fully grown and ready to pass on to its next life stage.^[7] A guest's relationship with its host may be intermittent or temporary, perhaps associated with multiple hosts, making the relationship equivalent to the herbivory of a wild-living animal. Another possibility is that the host-guest relationship may have no permanent physical contact, as in the brood parasitism of the cuckoo.^[6]

Hosts to parasites[edit]

Micropredator, parasite, parasitoid, and predator strategies compared. Their interactions with their hosts form a continuum. Micropredation and parasitoidism are now considered to be evolutionary strategies within parasitism.^[2]

Parasites follow a wide variety of evolutionary strategies, placing their hosts in an equally wide range of relationships.^[2] Parasitism implies host–parasite coevolution, including the maintenance of gene polymorphisms in the host, where there is a trade-off between the advantage of resistance to a parasite and a cost such as disease caused by the gene.^[8]

Definitive and secondary hosts[edit]

There are several kinds of host from a parasite's point of view.

A definitive or primary host is one in which a parasite reaches maturity and reproduces sexually. An intermediate host is one in which the parasite does not do this. A virus is an obligate parasite, acting as a living thing only to the extent that when it is in a host cell, the machinery of that cell makes copies of the virus.^[9] A reservoir host can harbour a pathogen indefinitely with no ill effects, with important implications for disease control. A single reservoir host may be reinfected several times.^[10] A host of predilection is the one preferred by a parasite.^[11] An amplifying host is one in which the level of pathogen can become high enough that a vector such as a mosquito that feeds on it will probably become infectious.^[12]

A secondary or intermediate host harbors a parasite only for a short transition period, during which (usually) some developmental stage is completed. For trypanosomes, the cause of sleeping sickness, strictly, humans are the secondary host, while the tsetse fly is the primary host, given that it has been shown that reproduction occurs in the insect.^[13] Tapeworms and other parasitic flatworms have complex lifecycles, in which specific developmental stages are completed in a sequence of several different hosts.^[14]

In trichinosis, the same host (such as humans or pigs) is both intermediate and definitive.

It is not always easy or even possible to identify which host is definitive and which secondary. As the life cycles of many parasites are not well understood, sometimes the subjectively more important organism is arbitrarily labelled as definitive, and this designation may continue even after it is found to be incorrect. For example, sludge worms are sometimes considered "intermediate hosts" for salmonid whirling disease, even though the myxosporean parasite reproduces sexually inside them.^[15] In trichinosis, a disease caused by roundworms, the host has reproductive adults in its digestive tract and immature juveniles in its muscles, and is therefore both an intermediate and a definitive host.^[16]

Paratenic hosts[edit]

A paratenic host is similar to an intermediate host, except that it is not needed for the parasite's development cycle to progress. Paratenic hosts serve as "dumps" for non-mature stages of a parasite in which they can accumulate in high numbers. The trematode Alaria americana may serve as an example: the so-called mesocercarial stages of this parasite reside in tadpoles, which are rarely eaten by the definitive canine host. The tadpoles are more frequently preyed on by snakes, in which the mesocercariae may not undergo further development. However, the parasites may accumulate in the snake paratenic host and infect the definitive host once the snake is consumed by a canid.^[17] The nematode Skrjabingylus nasicola is another example, with slugs as the intermediate hosts, shrews and rodents as the paratenic hosts, and mustelids as the definitive hosts.^[18]

Dead-end hosts[edit]

A dead-end or incidental host is an intermediate host that generally does not allow transmission to the definitive host, thereby preventing the parasite from completing its development. For example, humans and horses are dead-end hosts for West Nile virus, whose life-cycle is normally between culicine mosquitoes and birds.^[12] People and horses can become infected, but the level of virus in their blood does not become high enough to pass on the infection to mosquitoes that bite them.^[12]

Plant hosts of micropredators[edit]

Buff ermine moth caterpillar, a polyphagous micropredator

Micropredation is an evolutionarily stable strategy within parasitism, in which a small predator lives parasitically on a much larger host plant, eating parts of it.^[2]

The range of plants on which a herbivorous insect feeds is known as its host range. This can be wide or narrow, but it never includes all plants. A small number of insects are monophagous, feeding on a single plant. The silkworm larva is one of these, with mulberry leaves being the only food consumed. More often, an insect with a limited host range is oligophagous, being restricted to a few closely related species, usually in the same plant family.^[19] The diamondback moth is an example of this, feeding exclusively on brassicas,^[20] and the larva of the potato tuber moth feeds on potatoes, tomatoes and tobacco, all members of the same plant family, Solanaceae.^[21] Herbivorous insects with a wide range of hosts in various different plant families are known as polyphagous. One example is the buff ermine moth whose larvae feed on alder, mint, plantain, oak, rhubarb, currant, blackberry, dock, ragwort, nettle and honeysuckle.^[22]

Influenza virus can change by genetic reassortment as it travels between different hosts in its range.

Plants often produce toxic or unpalatable secondary metabolites to deter herbivores from feeding on them. Monophagous insects have developed specific adaptations to overcome those in their specialist hosts, giving them an advantage over polyphagous species. However, this puts them at greater risk of extinction if their chosen hosts suffer setbacks. Monophagous species are able to feed on the tender young foliage with high concentrations of damaging chemicals on which polyphagous species cannot feed, having to make do with older leaves. There is a trade off between offspring quality and quantity; the specialist maximises the chances of its young thriving by paying great attention to the choice of host, while the generalist produces larger numbers of eggs in sub-optimal conditions.^[23]

Some insect micropredators migrate regularly from one host to another. The hawthorn-carrot aphid overwinters on its primary host, a hawthorn tree, and migrates during the summer to its secondary host, a plant in the carrot family.^[24]

Host range[edit]

The host range is the set of hosts that a parasite can use as a partner. In the case of human parasites, the host range influences the epidemiology of the parasitism or disease. For instance, the production of antigenic shifts in Influenza A virus can result from pigs being infected with the virus from several different hosts (such as human and bird). This co-infection provides an opportunity for mixing of the viral genes between existing strains, thereby producing a new viral strain. An influenza vaccine produced against an existing viral strain might not be effective against this new strain, which then requires a new influenza vaccine to be prepared for the protection of the human population.^[25]

Non-parasitic associations[edit]

Mutualistic hosts[edit]

Mycorrhiza, a mutualistic interaction between a plant's roots and a fungus

Some hosts participate in fully mutualistic interactions with both organisms being completely dependent on the other. For example, termites are hosts to the protozoa that live in their gut and which digest cellulose,^[26] and the human gut flora is essential for efficient digestion.^[27] Many corals and other marine invertebrates house zooxanthellae, single-celled algae, in their tissues. The host provides a protected environment in a well-lit position for the algae, while benefiting itself from the nutrients produced by photosynthesis which supplement its diet.^[28] Lamellibrachia luymesi, a deep sea giant tubeworm, has an obligate mutualistic association with internal, sulfide-oxidizing, bacterial symbionts. The tubeworm extracts the chemicals that the bacteria need from the sediment, and the bacteria supply the tubeworm, which has no mouth, with nutrients.^[29] Some hermit crabs place pieces of sponge on the shell in which they are living. These grow over and eventually dissolve away the mollusc shell; the crab may not ever need to replace its abode again and is well-camouflaged by the overgrowth of sponge.^[30]

An important hosting relationship is mycorrhiza, a symbiotic association between a fungus and the roots of a vascular host plant. The fungus receives carbohydrates, the products of photosynthesis, while the plant receives phosphates and nitrogenous compounds acquired by the fungus from the soil. Over 95% of plant families have been shown to have mycorrhizal associations.^[31] Another such relationship is between leguminous plants and certain nitrogen-fixing bacteria called rhizobia that form nodules on the roots of the plant. The host supplies the bacteria with the energy needed for nitrogen fixation and the bacteria provide much of the nitrogen needed by the host. Such crops as beans, peas, chickpeas and alfalfa are able to fix nitrogen in this way,^[32] and mixing clover with grasses increases the yield of pastures.^[33]

Cleaning symbiosis: a Hawaiian cleaner wrasse with its client, a yellowtail wrasse

Hosts in cleaning symbiosis[edit]

Hosts of many species are involved in cleaning symbiosis, both in the sea and on land, making use of smaller animals to clean them of parasites. Cleaners include fish, shrimps and birds; hosts or clients include a much wider range of fish, marine reptiles including turtles and iguanas, octopus, whales, and terrestrial mammals.^[4] The host appears to benefit from the interaction, but biologists have disputed whether this is a truly mutualistic relationship or something closer to parasitism by the cleaner.^[34][35]

Nurse shark playing host to commensal remoras, which gain a free ride and which may serve as cleaners

Commensal hosts[edit]

Remoras (also called suckerfish) can swim freely but have evolved suckers that enable them to adhere to smooth surfaces, gaining a free ride (phoresis), and they spend most of their lives clinging to a host animal such as a whale, turtle or shark.^[3] However, the relationship may be mutualistic, as remoras, though not generally considered to be cleaner fish, often consume parasitic copepods: for example, these are found in the stomach contents of 70% of the common remora.^[36] Many molluscs, barnacles and polychaete worms attach themselves to the carapace of the Atlantic horseshoe crab; for some this is a convenient arrangement, but for others it is an obligate form of commensalism and they live nowhere else.^[26]

History[edit]

The first host to be noticed in ancient times was human: human parasites such as hookworm are recorded from ancient Egypt from 3000 BC onwards, while in ancient Greece, the Hippocratic Corpus describes human bladder worm.^[37] The medieval Persian physician Avicenna recorded human and animal parasites including roundworms, threadworms, the Guinea worm and tapeworms.^[37] In Early Modern times, Francesco Redi recorded animal parasites, while the microscopist Antonie van Leeuwenhoek observed and illustrated the protozoan Giardia lamblia from "his own loose stools".^[37]

Hosts to mutualistic symbionts were recognised more recently, when in 1877 Albert Bernhard Frank described the mutualistic relationship between a fungus and an alga in lichens.^[38]

See also[edit]

• PHI-base (Pathogen-Host Interaction database)

References[edit]