Hotan County is a county in the southwest of the Xinjiang Uyghur Autonomous Region and is under the administration of the Hotan Prefecture. Almost all the residents of the county are Uyghurs and live around oases situated between the desolate Taklamakan Desert and Kunlun Mountains. Hotan County is the southernmost county-level division of Xinjiang. The county borders Karakax/Moyu County to the northwest, Hotan City and Lop County to the northeast, Qira County to the east, Pishan County to the west, and Rutog County, Tibet to the southeast. Hotan County administers most of Aksai Chin, an area disputed between China and India. The Line of Actual Control divides the India-controlled part of Ladakh union territory from the Aksai Chin area administered as part of southwest Hotan County.

Hotan Prefecture is located in the Tarim Basin region of southwestern Xinjiang, China, bordering the Tibet Autonomous Region to the south and Union Territory of Ladakh and Gilgit-Baltistan to the west. The vast majority of the Aksai Chin region which is disputed between China and India is administered as part of Hotan Prefecture. The seat of Hotan Prefecture is Hotan and its largest county by population is Karakax County. The vast majority of the residents of the prefecture are Muslim Uyghurs and live around oases situated between the desolate Taklamakan Desert and Kunlun Mountains.