Hotel Astor was a hotel on Times Square in the Midtown Manhattan neighborhood of New York City, United States. Built in 1905 and expanded in 1909–1910 for the Astor family, the hotel occupied a site bounded by Broadway, Shubert Alley, and 44th and 45th Streets. Architects Clinton & Russell designed the hotel as an 11-story Beaux-Arts edifice with a mansard roof. It contained 1,000 guest rooms, with two more levels underground for its extensive "backstage" functions, such as the wine cellar.

Clinton and Russell was a well-known architectural firm founded in 1894 in New York City, United States. The firm was responsible for several New York City buildings, including some in Lower Manhattan.