The Hotel St. George is a building in Brooklyn Heights, Brooklyn, New York City. Built in sections between 1885 and 1930, the hotel was once the city's largest hotel, with 2,632 rooms at its peak. The hotel occupies the city block bounded by Pineapple Street, Henry Street, Clark Street, and Hicks Street.

Brooklyn Heights is a residential neighborhood within the New York City borough of Brooklyn. The neighborhood is bounded by Old Fulton Street near the Brooklyn Bridge on the north, Cadman Plaza West on the east, Atlantic Avenue on the south, and the Brooklyn–Queens Expressway or the East River on the west. Adjacent neighborhoods are Dumbo to the north, Downtown Brooklyn to the east, and Cobble Hill and Boerum Hill to the south.