The House of the First Printing Press in the Americas at the corner of Moneda and Licenciado Primo Verdad streets in Mexico City was the home of the first printing press/print shop in the New World. The printer Juan Pablos oversaw the printing of at least 35 books at this print shop between 1539, the date of the first book printed in the Americas, and his death in 1560.

Giovanni Paoli, better known as Juan Pablos, a native of Lombardy, was the first documented printer in the Americas when he started printing in Mexico in 1539.