The Houses of Refuge in Florida were a series of stations operated by the United States Life Saving Service along the coast of Florida to rescue and shelter ship-wrecked sailors. Five houses were constructed on the east coast in 1876, with five more added in 1885 and 1886. There were also two life-saving stations built, one just south of the Jupiter Inlet, the other on the Gulf coast on Santa Rosa Island near Pensacola, Florida. A house of refuge was planned for the Marquesas Keys, but was never put into commission. The houses were staffed by civilian contractors who lived in the houses with their families. Most of these houses remained in service as life-saving stations until 1915 or later. Some of the locations became United States Coast Guard stations after the Life-Saving Service was merged with the United States Revenue Cutter Service to form the Coast Guard in 1915.

The United States Life-Saving Service was a United States government agency that grew out of private and local humanitarian efforts to save the lives of shipwrecked mariners and passengers. It began in 1848 and ultimately merged with the Revenue Cutter Service to form the United States Coast Guard in 1915.