Howard County is located in the U.S. state of Missouri, with its southern border formed by the Missouri River. As of the 2020 census, the population was 10,151. Its county seat is Fayette. The county was organized January 23, 1816, and named for Benjamin Howard, the first Governor of the Missouri Territory. Settled originally by migrants from the Upper South, it is part of the region historically known as Little Dixie. It is part of the Columbia, Missouri, metropolitan area.

Fayette is a city in and the county seat of Howard County, Missouri, United States. It is part of the Columbia, Missouri Metropolitan Statistical Area. The city's population was 2,803 at the 2020 census.