The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, film director, and philanthropist, known during his lifetime as one of the most financially successful individuals in the world. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $825 million.

Howard Robard Hughes Jr. was an American aerospace engineer, business magnate, film producer, investor, philanthropist, and pilot. He was best known during his lifetime as one of the richest and most influential people in the world. He first became prominent as a film producer, and then as an important figure in the aviation industry. Later in life, he became known for his eccentric behavior and reclusive lifestyle—oddities that were caused in part by his worsening obsessive-compulsive disorder (OCD), chronic pain from a near-fatal plane crash, and increasing deafness.