Howard Street is a major north–south street through the central part of the city of Baltimore, Maryland. About 2+1⁄2 miles (4 km) long, the street begins at the north end of I-395 near Oriole Park at Camden Yards and ends near Johns Hopkins University, where it splits. To the right, it becomes Art Museum Drive, the one-block home of the Baltimore Museum of Art. To the left, it becomes San Martin Drive, which winds road along the western perimeter of the Johns Hopkins University campus and ends at University Parkway. Howard Street is named in honor of former Maryland governor John Eager Howard. Two other streets in Baltimore, John and Eager Streets, are also named after him.

Interstate 395 (I-395) is an auxiliary Interstate Highway in the US state of Maryland. Known as Cal Ripken Way, the highway runs 1.98 miles (3.19 km) from I-95 north to Howard Street and Camden Street in Downtown Baltimore, where it provides access to the Inner Harbor and the Baltimore Convention Center. The Interstate also serves the Camden Yards Sports Complex, which contains M&T Bank Stadium and Oriole Park at Camden Yards, homes of the Baltimore Ravens and Baltimore Orioles, respectively. I-395 also serves as the southern terminus of Martin Luther King Jr. Boulevard, an urban arterial that provides a western bypass of Downtown Baltimore and connects I-95 with U.S. Route 40 (US 40), US 1, and I-83. The Interstate is maintained by the Maryland Transportation Authority (MDTA) and, like all Interstates, is a part of the National Highway System.