The Hudson River Historic District, also known as Hudson River Heritage Historic District, is the largest Federally designated district on the mainland of the contiguous United States. It covers an area of 22,205 acres extending inland roughly a mile (1.6 km) from the east bank of the Hudson River between Staatsburg and Germantown in Dutchess and Columbia counties in the U.S. state of New York. This area includes the riverfront sections of the towns of Clermont, Red Hook, Rhinebeck and part of Hyde Park. This strip includes in their entirety the hamlets of Annandale, Barrytown, Rhinecliff and the village of Tivoli. Bard College and two protected areas, Margaret Lewis Norrie State Park and Tivoli Bays Unique Area, are also within the district.

Bard College is a private liberal arts college in the hamlet of Annandale-on-Hudson, in the town of Red Hook, in New York State. The campus overlooks the Hudson River and Catskill Mountains within the Hudson River Historic District—a National Historic Landmark.