Huerfano County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 6,820. The county seat is Walsenburg. The county, whose name comes from the Spanish huérfano meaning "orphan", was named for the Huerfano Butte, a local landmark. The area of Huerfano County boomed early in the 1900s with the discovery of large coal deposits. After large scale World War II coal demand ended in the 1940s Walsenburg and Huerfano saw a steady economic decline through 2015.

Walsenburg is the statutory city that is the county seat and the most populous municipality of Huerfano County, Colorado, United States. The city population was 3,049 at the 2020 census, down from 3,068 in 2010.