The Humen Pearl River Bridge (simplified Chinese: 虎门大桥; traditional Chinese: 虎門大橋; pinyin: Hǔmén Dàqiáo; Jyutping: Fu2mun4 Dai6kiu4) is a bridge over the Humen, Pearl River in Guangdong Province, southern China. It consists of two main spans — a suspension bridge section and a segmental concrete section. It connects the Nansha District of Guangzhou to Humen Town of Dongguan. Completed in 1997, the suspension bridge has a main span of 888 meters, and the segmental concrete section's main span of 237 meters is among the longest such spans in the world. It forms part of the G9411 Dongguan–Foshan Expressway. A newer bridge known as Nansha Bridge (Chinese: 南沙大桥), built to reduce the traffic problems on the Humen Bridge, opened to traffic in April 2019.

The Humen, also Bocca Tigris or Bogue, is a narrow strait in the Pearl River Delta that separates Shiziyang in the north and Lingdingyang in the south near Humen Town in China's Guangdong Province. It is the site of the Pearl River's discharge into the South China Sea. It contains the Port of Humen at Humen Town. The strait is formed by the islands of Chuenpi and Anunghoy on the eastern side, and Taikoktow on the western side. Since 1997, the strait has been traversed by the Humen Pearl River Bridge. Bocca Tigris was the entry to China's only trading city, Canton.