Humphreys County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 7,785. Its county seat is Belzoni. The county is named for Benjamin G. Humphreys. Humphreys County is Mississippi's newest county, having been formed in 1918. Humphreys County is located in the Mississippi Delta region.

Belzoni is a city in Humphreys County, Mississippi, United States, in the Mississippi Delta region, on the Yazoo River. The population was 2,235 at the 2010 census. It is the county seat of Humphreys County. It was named for the 19th-century Italian archaeologist/explorer Giovanni Battista Belzoni.