Hurricane Inez was a powerful Category 5 major hurricane that affected the Caribbean, Bahamas, Florida, and Mexico, killing over 1,000 people in 1966. It was the first storm on record to affect all of those areas. It originated from a tropical wave over Africa, and became a tropical depression by September 21. It moved slowly westward, initially failing to intensify much; it was upgraded to Tropical Storm Inez on September 24. The storm strengthened into a hurricane and was quickly intensifying when it struck the French overseas region of Guadeloupe on September 27. Inez severely damaged the island's banana and sugar crops, and thousands of homes were damaged, leaving 10,000 people homeless. Damage on Guadeloupe was estimated at $50 million, and there were 40 deaths. After entering the Caribbean, Inez briefly weakened before restrengthening, attaining peak sustained winds of 165 mph (270 km/h) on September 28, eventually making landfall at that intensity in the Dominican Republic. That day a hurricane hunters flight reported a gust of 197 mph (317 km/h), which was the highest recorded at the time.

Guadeloupe is an overseas department of France in the Caribbean. It consists of six inhabited islands—Basse-Terre, Grande-Terre, Marie-Galante, La Désirade, and two Îles des Saintes—as well as many uninhabited islands and outcroppings. It is south of Antigua and Barbuda and Montserrat and north of Dominica. The capital city is Basse-Terre, on the southern west coast of Basse-Terre Island; the most populous city is Les Abymes and the main centre of business is neighbouring Pointe-à-Pitre, both on Grande-Terre Island. It had a population of 395,726 in 2024.