Huslia is a city in Yukon-Koyukuk Census Area, Alaska, United States. Rarely known as Hussliakatna, it is inhabited by Koyukuk-hotana Athabascans. The population was 293 at the 2000 census and 275 as of the 2010 census.

Yukon–Koyukuk Census Area is a census area in the U.S. state of Alaska. As of the 2020 census, the population was 5,343, down from 5,588 in 2010. With an area of 147,842.51 sq mi (382,910.3 km2), it is the largest of any county or county-equivalent in the United States, or slightly larger than the entire state of Montana. It is part of the unorganized borough of Alaska and therefore has no borough seat. Its largest communities are the cities of Galena, in the west, and Fort Yukon, in the northeast.