Hyannis is the largest of the seven villages in the town of Barnstable, Massachusetts, United States. It is the commercial and transportation hub of Cape Cod and was designated an urban area at the 1990 census. Because of this, many refer to Hyannis as the "Capital of the Cape". It contains a majority of the Barnstable Town offices and two important shopping districts: the historic downtown Main Street and the Route 132 Commercial District, including Cape Cod Mall and Independence Park, headquarters of Cape Cod Potato Chips. Cape Cod Hospital in Hyannis is the largest on Cape Cod.

Barnstable is a town in the U.S. state of Massachusetts and the county seat of Barnstable County. Barnstable is the largest community, both in land area and population, on Cape Cod, and is one of thirteen Massachusetts municipalities that have been granted city forms of government by the Commonwealth of Massachusetts but wish to retain "the town of" in their official names. At the 2020 census it had a population of 48,916. The town contains several villages within its boundaries. Its largest village, Hyannis, is the central business district of the county and home to Barnstable Municipal Airport, the airline hub of Cape Cod and the islands of Martha's Vineyard and Nantucket. Additionally, Barnstable is a 2007 winner of the All-America City Award.