1.
Jmol
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Jmol is computer software for molecular modelling chemical structures in 3-dimensions. Jmol returns a 3D representation of a molecule that may be used as a teaching tool and it is written in the programming language Java, so it can run on the operating systems Windows, macOS, Linux, and Unix, if Java is installed. It is free and open-source software released under a GNU Lesser General Public License version 2.0, a standalone application and a software development kit exist that can be integrated into other Java applications, such as Bioclipse and Taverna. A popular feature is an applet that can be integrated into web pages to display molecules in a variety of ways, for example, molecules can be displayed as ball-and-stick models, space-filling models, ribbon diagrams, etc. Jmol supports a range of chemical file formats, including Protein Data Bank, Crystallographic Information File, MDL Molfile. There is also a JavaScript-only version, JSmol, that can be used on computers with no Java, the Jmol applet, among other abilities, offers an alternative to the Chime plug-in, which is no longer under active development. While Jmol has many features that Chime lacks, it does not claim to reproduce all Chime functions, most notably, Chime requires plug-in installation and Internet Explorer 6.0 or Firefox 2.0 on Microsoft Windows, or Netscape Communicator 4.8 on Mac OS9. Jmol requires Java installation and operates on a variety of platforms. For example, Jmol is fully functional in Mozilla Firefox, Internet Explorer, Opera, Google Chrome, fast and Scriptable Molecular Graphics in Web Browsers without Java3D
2.
ChemSpider
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ChemSpider is a database of chemicals. ChemSpider is owned by the Royal Society of Chemistry, the database contains information on more than 50 million molecules from over 500 data sources including, Each chemical is given a unique identifier, which forms part of a corresponding URL. This is an approach to develop an online chemistry database. The search can be used to widen or restrict already found results, structure searching on mobile devices can be done using free apps for iOS and for the Android. The ChemSpider database has been used in combination with text mining as the basis of document markup. The result is a system between chemistry documents and information look-up via ChemSpider into over 150 data sources. ChemSpider was acquired by the Royal Society of Chemistry in May,2009, prior to the acquisition by RSC, ChemSpider was controlled by a private corporation, ChemZoo Inc. The system was first launched in March 2007 in a release form. ChemSpider has expanded the generic support of a database to include support of the Wikipedia chemical structure collection via their WiChempedia implementation. A number of services are available online. SyntheticPages is an interactive database of synthetic chemistry procedures operated by the Royal Society of Chemistry. Users submit synthetic procedures which they have conducted themselves for publication on the site and these procedures may be original works, but they are more often based on literature reactions. Citations to the published procedure are made where appropriate. They are checked by an editor before posting. The pages do not undergo formal peer-review like a journal article. The comments are moderated by scientific editors. The intention is to collect practical experience of how to conduct useful chemical synthesis in the lab, while experimental methods published in an ordinary academic journal are listed formally and concisely, the procedures in ChemSpider SyntheticPages are given with more practical detail. Comments by submitters are included as well, other publications with comparable amounts of detail include Organic Syntheses and Inorganic Syntheses
3.
PubChem
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PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information, a component of the National Library of Medicine, PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be downloaded via FTP. PubChem contains substance descriptions and small molecules with fewer than 1000 atoms and 1000 bonds, more than 80 database vendors contribute to the growing PubChem database. PubChem consists of three dynamically growing primary databases, as of 28 January 2016, Compounds,82.6 million entries, contains pure and characterized chemical compounds. Substances,198 million entries, contains also mixtures, extracts, complexes, bioAssay, bioactivity results from 1.1 million high-throughput screening programs with several million values. PubChem contains its own online molecule editor with SMILES/SMARTS and InChI support that allows the import and export of all common chemical file formats to search for structures and fragments. In the text search form the database fields can be searched by adding the name in square brackets to the search term. A numeric range is represented by two separated by a colon. The search terms and field names are case-insensitive, parentheses and the logical operators AND, OR, and NOT can be used. AND is assumed if no operator is used, example,0,5000,50,10 -5,5 PubChem was released in 2004. The American Chemical Society has raised concerns about the publicly supported PubChem database and they have a strong interest in the issue since the Chemical Abstracts Service generates a large percentage of the societys revenue. To advocate their position against the PubChem database, ACS has actively lobbied the US Congress, soon after PubChems creation, the American Chemical Society lobbied U. S. Congress to restrict the operation of PubChem, which they asserted competes with their Chemical Abstracts Service
4.
International Chemical Identifier
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Initially developed by IUPAC and NIST from 2000 to 2005, the format and algorithms are non-proprietary. The continuing development of the standard has supported since 2010 by the not-for-profit InChI Trust. The current version is 1.04 and was released in September 2011, prior to 1.04, the software was freely available under the open source LGPL license, but it now uses a custom license called IUPAC-InChI Trust License. Not all layers have to be provided, for instance, the layer can be omitted if that type of information is not relevant to the particular application. InChIs can thus be seen as akin to a general and extremely formalized version of IUPAC names and they can express more information than the simpler SMILES notation and differ in that every structure has a unique InChI string, which is important in database applications. Information about the 3-dimensional coordinates of atoms is not represented in InChI, the InChI algorithm converts input structural information into a unique InChI identifier in a three-step process, normalization, canonicalization, and serialization. The InChIKey, sometimes referred to as a hashed InChI, is a fixed length condensed digital representation of the InChI that is not human-understandable. The InChIKey specification was released in September 2007 in order to facilitate web searches for chemical compounds and it should be noted that, unlike the InChI, the InChIKey is not unique, though collisions can be calculated to be very rare, they happen. In January 2009 the final 1.02 version of the InChI software was released and this provided a means to generate so called standard InChI, which does not allow for user selectable options in dealing with the stereochemistry and tautomeric layers of the InChI string. The standard InChIKey is then the hashed version of the standard InChI string, the standard InChI will simplify comparison of InChI strings and keys generated by different groups, and subsequently accessed via diverse sources such as databases and web resources. Every InChI starts with the string InChI= followed by the version number and this is followed by the letter S for standard InChIs. The remaining information is structured as a sequence of layers and sub-layers, the layers and sub-layers are separated by the delimiter / and start with a characteristic prefix letter. The six layers with important sublayers are, Main layer Chemical formula and this is the only sublayer that must occur in every InChI. The atoms in the formula are numbered in sequence, this sublayer describes which atoms are connected by bonds to which other ones. Describes how many hydrogen atoms are connected to each of the other atoms, the condensed,27 character standard InChIKey is a hashed version of the full standard InChI, designed to allow for easy web searches of chemical compounds. Most chemical structures on the Web up to 2007 have been represented as GIF files, the full InChI turned out to be too lengthy for easy searching, and therefore the InChIKey was developed. With all databases currently having below 50 million structures, such duplication appears unlikely at present, a recent study more extensively studies the collision rate finding that the experimental collision rate is in agreement with the theoretical expectations. Example, Morphine has the structure shown on the right, as the InChI cannot be reconstructed from the InChIKey, an InChIKey always needs to be linked to the original InChI to get back to the original structure
5.
Simplified molecular-input line-entry system
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The simplified molecular-input line-entry system is a specification in form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules, the original SMILES specification was initiated in the 1980s. It has since modified and extended. In 2007, a standard called OpenSMILES was developed in the open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. The Environmental Protection Agency funded the project to develop SMILES. It has since modified and extended by others, most notably by Daylight Chemical Information Systems. In 2007, a standard called OpenSMILES was developed by the Blue Obelisk open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, in July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is generally considered to have the advantage of being slightly more human-readable than InChI, the term SMILES refers to a line notation for encoding molecular structures and specific instances should strictly be called SMILES strings. However, the term SMILES is also used to refer to both a single SMILES string and a number of SMILES strings, the exact meaning is usually apparent from the context. The terms canonical and isomeric can lead to confusion when applied to SMILES. The terms describe different attributes of SMILES strings and are not mutually exclusive, typically, a number of equally valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol, algorithms have been developed to generate the same SMILES string for a given molecule, of the many possible strings, these algorithms choose only one of them. This SMILES is unique for each structure, although dependent on the algorithm used to generate it. These algorithms first convert the SMILES to a representation of the molecular structure. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database, there is currently no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, and these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES
6.
Chemical formula
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These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, the simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the numbers of each type of atom in a molecule. For example, the formula for glucose is CH2O, while its molecular formula is C6H12O6. This is possible if the relevant bonding is easy to show in one dimension, an example is the condensed molecular/chemical formula for ethanol, which is CH3-CH2-OH or CH3CH2OH. For reasons of structural complexity, there is no condensed chemical formula that specifies glucose, chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. A chemical formula identifies each constituent element by its chemical symbol, in empirical formulas, these proportions begin with a key element and then assign numbers of atoms of the other elements in the compound, as ratios to the key element. For molecular compounds, these numbers can all be expressed as whole numbers. For example, the formula of ethanol may be written C2H6O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of compounds, however, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CBn is a variable non-whole number ratio with n ranging from over 4 to more than 6.5. When the chemical compound of the consists of simple molecules. These types of formulas are known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the formula for glucose is C6H12O6 rather than the glucose empirical formula. However, except for very simple substances, molecular chemical formulas lack needed structural information, for simple molecules, a condensed formula is a type of chemical formula that may fully imply a correct structural formula. For example, ethanol may be represented by the chemical formula CH3CH2OH
7.
Hydrogen fluoride
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Hydrogen fluoride is a chemical compound with the chemical formula HF. This colorless gas or liquid is the principal source of fluorine. It is an important feedstock in the preparation of many important compounds including pharmaceuticals, HF is widely used in the petrochemical industry as a component of superacids. Hydrogen fluoride boils near room temperature, much higher than other hydrogen halides, unlike other hydrogen halides, HF is lighter than air. Hydrogen fluoride is a dangerous gas, forming corrosive and penetrating hydrofluoric acid upon contact with moisture. The gas can cause blindness by rapid destruction of the corneas. French chemist Edmond Frémy is credited with discovering anhydrous hydrogen fluoride while trying to isolate fluorine, although Carl Wilhelm Scheele prepared hydrofluoric acid in large quantities in 1771, this acid was known in the glass industry before then. Although a diatomic molecule, HF forms relatively strong intermolecular hydrogen bonds, solid HF consists of zigzag chains of HF molecules. The HF molecules, with a short H–F bond of 95 pm, are linked to neighboring molecules by intermolecular H–F distances of 155 pm, liquid HF also consists of chains of HF molecules, but the chains are shorter, consisting on average of only five or six molecules. Hydrogen fluoride does not boil until 20 °C in contrast to the hydrogen halides which boil between −85 °C and −35 °C. This hydrogen bonding between HF molecules gives rise to high viscosity in the phase and lower than expected pressure in the gas phase. Hydrogen fluoride is miscible with water, whereas the hydrogen halides have large solubility gaps with water. Hydrogen fluoride and water also form compounds in the solid state, most notably a 1,1 compound that does not melt until −40 °C. Unlike other hydrohalic acids, such as acid, hydrogen fluoride is only a weak acid in dilute aqueous solution. This is in part a result of the strength of the bond, but also of other factors such as the tendency of HF, H 2O. At high concentrations, HF molecules undergo homoassociation to form polyatomic ions and protons and this leads to protonation of very strong acids like hydrochloric, sulfuric, or nitric when using concentrated hydrofluoric acid solutions. Although hydrofluoric acid is regarded as an acid, it is very corrosive. The acidity of hydrofluoric acid solutions varies with concentration owing to hydrogen-bond interactions of the fluoride ion, dilute solutions are weakly acidic with an acid ionization constant Ka =6. 6×10−4, in contrast to corresponding solutions of the other hydrogen halides which are strong acids
8.
Density
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The density, or more precisely, the volumetric mass density, of a substance is its mass per unit volume. The symbol most often used for density is ρ, although the Latin letter D can also be used. Mathematically, density is defined as mass divided by volume, ρ = m V, where ρ is the density, m is the mass, and V is the volume. In some cases, density is defined as its weight per unit volume. For a pure substance the density has the numerical value as its mass concentration. Different materials usually have different densities, and density may be relevant to buoyancy, purity, osmium and iridium are the densest known elements at standard conditions for temperature and pressure but certain chemical compounds may be denser. Thus a relative density less than one means that the floats in water. The density of a material varies with temperature and pressure and this variation is typically small for solids and liquids but much greater for gases. Increasing the pressure on an object decreases the volume of the object, increasing the temperature of a substance decreases its density by increasing its volume. In most materials, heating the bottom of a results in convection of the heat from the bottom to the top. This causes it to rise relative to more dense unheated material, the reciprocal of the density of a substance is occasionally called its specific volume, a term sometimes used in thermodynamics. Density is a property in that increasing the amount of a substance does not increase its density. Archimedes knew that the irregularly shaped wreath could be crushed into a cube whose volume could be calculated easily and compared with the mass, upon this discovery, he leapt from his bath and ran naked through the streets shouting, Eureka. As a result, the term eureka entered common parlance and is used today to indicate a moment of enlightenment, the story first appeared in written form in Vitruvius books of architecture, two centuries after it supposedly took place. Some scholars have doubted the accuracy of this tale, saying among other things that the method would have required precise measurements that would have been difficult to make at the time, from the equation for density, mass density has units of mass divided by volume. As there are units of mass and volume covering many different magnitudes there are a large number of units for mass density in use. The SI unit of kilogram per metre and the cgs unit of gram per cubic centimetre are probably the most commonly used units for density.1,000 kg/m3 equals 1 g/cm3. In industry, other larger or smaller units of mass and or volume are often more practical, see below for a list of some of the most common units of density
9.
Melting point
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The melting point of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure. At the melting point the solid and liquid phase exist in equilibrium, the melting point of a substance depends on pressure and is usually specified at standard pressure. When considered as the temperature of the change from liquid to solid. Because of the ability of some substances to supercool, the point is not considered as a characteristic property of a substance. For most substances, melting and freezing points are approximately equal, for example, the melting point and freezing point of mercury is 234.32 kelvins. However, certain substances possess differing solid-liquid transition temperatures, for example, agar melts at 85 °C and solidifies from 31 °C to 40 °C, such direction dependence is known as hysteresis. The melting point of ice at 1 atmosphere of pressure is close to 0 °C. In the presence of nucleating substances the freezing point of water is the same as the melting point, the chemical element with the highest melting point is tungsten, at 3687 K, this property makes tungsten excellent for use as filaments in light bulbs. Many laboratory techniques exist for the determination of melting points, a Kofler bench is a metal strip with a temperature gradient. Any substance can be placed on a section of the strip revealing its thermal behaviour at the temperature at that point, differential scanning calorimetry gives information on melting point together with its enthalpy of fusion. A basic melting point apparatus for the analysis of crystalline solids consists of an oil bath with a transparent window, the several grains of a solid are placed in a thin glass tube and partially immersed in the oil bath. The oil bath is heated and with the aid of the melting of the individual crystals at a certain temperature can be observed. In large/small devices, the sample is placed in a heating block, the measurement can also be made continuously with an operating process. For instance, oil refineries measure the point of diesel fuel online, meaning that the sample is taken from the process. This allows for more frequent measurements as the sample does not have to be manually collected, for refractory materials the extremely high melting point may be determined by heating the material in a black body furnace and measuring the black-body temperature with an optical pyrometer. For the highest melting materials, this may require extrapolation by several hundred degrees, the spectral radiance from an incandescent body is known to be a function of its temperature. An optical pyrometer matches the radiance of a body under study to the radiance of a source that has been previously calibrated as a function of temperature, in this way, the measurement of the absolute magnitude of the intensity of radiation is unnecessary. However, known temperatures must be used to determine the calibration of the pyrometer, for temperatures above the calibration range of the source, an extrapolation technique must be employed
10.
Boiling point
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The boiling point of a substance is the temperature at which the vapor pressure of the liquid equals the pressure surrounding the liquid and the liquid changes into a vapor. The boiling point of a liquid varies depending upon the environmental pressure. A liquid in a vacuum has a lower boiling point than when that liquid is at atmospheric pressure. A liquid at high pressure has a boiling point than when that liquid is at atmospheric pressure. For a given pressure, different liquids boil at different temperatures, for example, water boils at 100 °C at sea level, but at 93.4 °C at 2,000 metres altitude. The normal boiling point of a liquid is the case in which the vapor pressure of the liquid equals the defined atmospheric pressure at sea level,1 atmosphere. At that temperature, the pressure of the liquid becomes sufficient to overcome atmospheric pressure. The standard boiling point has been defined by IUPAC since 1982 as the temperature at which boiling occurs under a pressure of 1 bar, the heat of vaporization is the energy required to transform a given quantity of a substance from a liquid into a gas at a given pressure. Liquids may change to a vapor at temperatures below their boiling points through the process of evaporation, evaporation is a surface phenomenon in which molecules located near the liquids edge, not contained by enough liquid pressure on that side, escape into the surroundings as vapor. On the other hand, boiling is a process in which molecules anywhere in the liquid escape, a saturated liquid contains as much thermal energy as it can without boiling. The saturation temperature is the temperature for a corresponding saturation pressure at which a liquid boils into its vapor phase, the liquid can be said to be saturated with thermal energy. Any addition of energy results in a phase transition. If the pressure in a system remains constant, a vapor at saturation temperature will begin to condense into its liquid phase as thermal energy is removed, similarly, a liquid at saturation temperature and pressure will boil into its vapor phase as additional thermal energy is applied. The boiling point corresponds to the temperature at which the pressure of the liquid equals the surrounding environmental pressure. Thus, the point is dependent on the pressure. Boiling points may be published with respect to the NIST, USA standard pressure of 101.325 kPa, at higher elevations, where the atmospheric pressure is much lower, the boiling point is also lower. The boiling point increases with increased pressure up to the critical point, the boiling point cannot be increased beyond the critical point. Likewise, the point decreases with decreasing pressure until the triple point is reached
11.
Aqueous solution
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An aqueous solution is a solution in which the solvent is water. It is usually shown in chemical equations by appending to the relevant chemical formula, for example, a solution of table salt, or sodium chloride, in water would be represented as Na+ + Cl−. The word aqueous means pertaining to, related to, similar to, as water is an excellent solvent and is also naturally abundant, it is a ubiquitous solvent in chemistry. Substances that are hydrophobic often do not dissolve well in water, an example of a hydrophilic substance is sodium chloride. Acids and bases are aqueous solutions, as part of their Arrhenius definitions, the ability of a substance to dissolve in water is determined by whether the substance can match or exceed the strong attractive forces that water molecules generate between themselves. If the substance lacks the ability to dissolve in water the molecules form a precipitate, reactions in aqueous solutions are usually metathesis reactions. Metathesis reactions are another term for double-displacement, that is, when a cation displaces to form a bond with the other anion. The cation bonded with the latter anion will dissociate and bond with the other anion, aqueous solutions that conduct electric current efficiently contain strong electrolytes, while ones that conduct poorly are considered to have weak electrolytes. Those strong electrolytes are substances that are ionized in water. Nonelectrolytes are substances that dissolve in water yet maintain their molecular integrity, examples include sugar, urea, glycerol, and methylsulfonylmethane. When writing the equations of reactions, it is essential to determine the precipitate. To determine the precipitate, one must consult a chart of solubility, soluble compounds are aqueous, while insoluble compounds are the precipitate. Remember that there may not always be a precipitate, when performing calculations regarding the reacting of one or more aqueous solutions, in general one must know the concentration, or molarity, of the aqueous solutions. Solution concentration is given in terms of the form of the prior to it dissolving. Metal ions in aqueous solution Solubility Dissociation Acid-base reaction theories Properties of water Zumdahl S.1997, 4th ed. Boston, Houghton Mifflin Company
12.
Miscibility
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Miscibility /mɪsᵻˈbɪlᵻti/ is the property of substances to mix in all proportions, forming a homogeneous solution. The term is most often applied to liquids, but applies also to solids, water and ethanol, for example, are miscible because they mix in all proportions. By contrast, substances are said to be if a significant proportion does not form a solution. Otherwise, the substances are considered miscible, for example, butanone is significantly soluble in water, but these two solvents are not miscible because they are not soluble in all proportions. In organic compounds, the percent of hydrocarbon chain often determines the compounds miscibility with water. For example, among the alcohols, ethanol has two atoms and is miscible with water, whereas 1-octanol with eight carbons is not. Octanols immiscibility leads it to be used as a standard for partition equilibria and this is also the case with lipids, the very long carbon chains of lipids cause them almost always to be immiscible with water. Analogous situations occur for other functional groups, acetic acid is miscible with water, whereas valeric acid is not. Immiscible metals are unable to form alloys with each other, typically, a mixture will be possible in the molten state, but upon freezing the metals separate into layers. This property allows solid precipitates to be formed by freezing a molten mixture of immiscible metals. One example of immiscibility in metals is copper and cobalt, where rapid freezing to form solid precipitates has been used to create granular GMR materials, there also exist metals that are immiscible in the liquid state. One with industrial importance is that liquid zinc and liquid silver are immiscible in liquid lead and this leads to the Parkes process, an example of liquid-liquid extraction, whereby lead containing any amount of silver is melted with zinc. The silver migrates to the zinc, which is skimmed off the top of the liquid. Substances with extremely low configurational entropy, especially polymers, are likely to be immiscible in one even in the liquid state. Miscibility of two materials is often determined optically, when the two miscible liquids are combined, the resulting liquid is clear. If the mixture is cloudy the two materials are immiscible, care must be taken with this determination. If the indices of refraction of the two materials are similar, an immiscible mixture may be clear and give an incorrect determination that the two liquids are miscible, miscibility gap Emulsion Heteroazeotrope ITIES Multiphasic liquid
13.
Acid dissociation constant
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An acid dissociation constant, Ka, is a quantitative measure of the strength of an acid in solution. It is the constant for a chemical reaction known as dissociation in the context of acid–base reactions. In the example shown in the figure, HA represents acetic acid, and A− represents the acetate ion, the chemical species HA, A− and H3O+ are said to be in equilibrium when their concentrations do not change with the passing of time. The definition can then be more simply H A ⇌ A − + H +, K a = This is the definition in common usage. A weak acid has a pKa value in the approximate range −2 to 12 in water, pKa values for strong acids can, however, be estimated by theoretical means. The definition can be extended to non-aqueous solvents, such as acetonitrile and dimethylsulfoxide. Denoting a solvent molecule by S H A + S ⇌ A − + S H +, K a = When the concentration of solvent molecules can be taken to be constant, K a =, as before. The value of pKa also depends on structure of the acid in many ways. For example, Pauling proposed two rules, one for successive pKa of polyprotic acids, and one to estimate the pKa of oxyacids based on the number of =O and −OH groups. Other structural factors that influence the magnitude of the dissociation constant include inductive effects, mesomeric effects. Hammett type equations have frequently applied to the estimation of pKa. The quantitative behaviour of acids and bases in solution can be only if their pKa values are known. These calculations find application in different areas of chemistry, biology, medicine. Acid dissociation constants are essential in aquatic chemistry and chemical oceanography. In living organisms, acid–base homeostasis and enzyme kinetics are dependent on the pKa values of the acids and bases present in the cell. According to Arrheniuss original definition, an acid is a substance that dissociates in solution, releasing the hydrogen ion H+. The equilibrium constant for this reaction is known as a dissociation constant. Brønsted and Lowry generalised this further to an exchange reaction
14.
Safety data sheet
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A safety data sheet, material safety data sheet, or product safety data sheet is an important component of product stewardship, occupational safety and health, and spill-handling procedures. SDS formats can vary from source to source within a country depending on national requirements, SDSs are a widely used system for cataloging information on chemicals, chemical compounds, and chemical mixtures. SDS information may include instructions for the use and potential hazards associated with a particular material or product. The SDS should be available for reference in the area where the chemicals are being stored or in use, there is also a duty to properly label substances on the basis of physico-chemical, health and/or environmental risk. Labels can include hazard symbols such as the European Union standard symbols, a SDS for a substance is not primarily intended for use by the general consumer, focusing instead on the hazards of working with the material in an occupational setting. It is important to use an SDS specific to country and supplier, as the same product can have different formulations in different countries. The formulation and hazard of a product using a name may vary between manufacturers in the same country. Safety data sheets have made an integral part of the system of Regulation No 1907/2006. The SDS must be supplied in a language of the Member State where the substance or mixture is placed on the market. The 16 sections are, SECTION1, Identification of the substance/mixture, relevant identified uses of the substance or mixture and uses advised against 1.3. Details of the supplier of the safety data sheet 1.4, Emergency telephone number SECTION2, Hazards identification 2.1. Classification of the substance or mixture 2.2, Other hazards SECTION3, Composition/information on ingredients 3.1. Mixtures SECTION4, First aid measures 4.1, Description of first aid measures 4.2. Most important symptoms and effects, both acute and delayed 4.3, indication of any immediate medical attention and special treatment needed SECTION5, Firefighting measures 5.1. Special hazards arising from the substance or mixture 5.3, advice for firefighters SECTION6, Accidental release measure 6.1. Personal precautions, protective equipment and emergency procedures 6.2, methods and material for containment and cleaning up 6.4. Reference to other sections SECTION7, Handling and storage 7.1, conditions for safe storage, including any incompatibilities 7.3. Specific end use SECTION8, Exposure controls/personal protection 8.1, Exposure controls SECTION9, Physical and chemical properties 9.1
15.
GHS hazard pictograms
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Hazard pictograms form part of the international Globally Harmonized System of Classification and Labelling of Chemicals. Two sets of pictograms are included within the GHS, one for the labelling of containers and for workplace hazard warnings, either one or the other is chosen, depending on the target audience, but the two are not used together. The two sets of use the same symbols for the same hazards, although certain symbols are not required for transport pictograms. Transport pictograms come in variety of colors and may contain additional information such as a subcategory number. It has still to be implemented by the European Union in 2009, the following pictograms are included in the Worldwide Model Using but have not been incorporated into the GHS, ICZ and Catwallsh Hazcom Labelling because of the nature of the hazards. Globally Harmonized System of Classification and Labelling of Chemicals, New York and Geneva, United Nations,2007, ISBN 978-92-1-116957-7, ST/SG/AC. 10/30/Rev. Model Regulations, New York and Geneva, United Nations,2007, ISBN 978-92-1-139120-6, manual of Tests and Criteria, New York and Geneva, United Nations,2002, ISBN 92-1-139087-7, ST/SG/AC. 10/11/Rev.4 GHS pictogram gallery from the United Nations Economic Commission for Europe
16.
Flash point
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The flash point is the lowest temperature at which vapours of a volatile material will ignite, when given an ignition source. The flash point may sometimes be confused with the autoignition temperature, the fire point is the lowest temperature at which the vapor will keep burning after being ignited and the ignition source removed. The fire point is higher than the point, because at the flash point the vapor may be reliably expected to cease burning when the ignition source is removed. The flash point is a characteristic that is used to distinguish between flammable liquids, such as petrol, and combustible liquids, such as diesel. It is also used to characterize the fire hazards of liquids, all liquids have a specific vapor pressure, which is a function of that liquids temperature and is subject to Boyles Law. As temperature increases, vapor pressure increases, as vapor pressure increases, the concentration of vapor of a flammable or combustible liquid in the air increases. Hence, temperature determines the concentration of vapor of the liquid in the air. The flash point is the lowest temperature at which there will be enough flammable vapor to induce ignition when a source is applied. There are two types of flash point measurement, open cup and closed cup. In open cup devices, the sample is contained in a cup which is heated and, at intervals. The measured flash point will vary with the height of the flame above the liquid surface and, at sufficient height. The best-known example is the Cleveland open cup, in both these types, the cups are sealed with a lid through which the ignition source can be introduced. Closed cup testers normally give lower values for the point than open cup and are a better approximation to the temperature at which the vapour pressure reaches the lower flammable limit. The flash point is an empirical measurement rather than a physical parameter. The measured value will vary with equipment and test protocol variations, including temperature ramp rate, time allowed for the sample to equilibrate, sample volume, methods for determining the flash point of a liquid are specified in many standards. For example, testing by the Pensky-Martens closed cup method is detailed in ASTM D93, IP34, ISO2719, DIN51758, JIS K2265 and AFNOR M07-019. Determination of flash point by the Small Scale closed cup method is detailed in ASTM D3828 and D3278, EN ISO3679 and 3680, cEN/TR15138 Guide to Flash Point Testing and ISO TR29662 Guidance for Flash Point Testing cover the key aspects of flash point testing. Gasoline is a used in a spark-ignition engine
17.
Ion
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An ion is an atom or a molecule in which the total number of electrons is not equal to the total number of protons, giving the atom or molecule a net positive or negative electrical charge. Ions can be created, by chemical or physical means. In chemical terms, if an atom loses one or more electrons. If an atom gains electrons, it has a net charge and is known as an anion. Ions consisting of only a single atom are atomic or monatomic ions, because of their electric charges, cations and anions attract each other and readily form ionic compounds, such as salts. In the case of ionization of a medium, such as a gas, which are known as ion pairs are created by ion impact, and each pair consists of a free electron. The word ion comes from the Greek word ἰόν, ion, going and this term was introduced by English physicist and chemist Michael Faraday in 1834 for the then-unknown species that goes from one electrode to the other through an aqueous medium. Faraday also introduced the words anion for a charged ion. In Faradays nomenclature, cations were named because they were attracted to the cathode in a galvanic device, arrhenius explanation was that in forming a solution, the salt dissociates into Faradays ions. Arrhenius proposed that ions formed even in the absence of an electric current, ions in their gas-like state are highly reactive, and do not occur in large amounts on Earth, except in flames, lightning, electrical sparks, and other plasmas. These gas-like ions rapidly interact with ions of charge to give neutral molecules or ionic salts. These stabilized species are commonly found in the environment at low temperatures. A common example is the present in seawater, which are derived from the dissolved salts. Electrons, due to their mass and thus larger space-filling properties as matter waves, determine the size of atoms. Thus, anions are larger than the parent molecule or atom, as the excess electron repel each other, as such, in general, cations are smaller than the corresponding parent atom or molecule due to the smaller size of its electron cloud. One particular cation contains no electrons, and thus consists of a single proton - very much smaller than the parent hydrogen atom. Since the electric charge on a proton is equal in magnitude to the charge on an electron, an anion, from the Greek word ἄνω, meaning up, is an ion with more electrons than protons, giving it a net negative charge. A cation, from the Greek word κατά, meaning down, is an ion with fewer electrons than protons, there are additional names used for ions with multiple charges
18.
Hydrochloric acid
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Hydrochloric acid is a corrosive, strong mineral acid with many industrial uses. A colorless, highly pungent solution of chloride in water. Free hydrochloric acid was first formally described in the 16th century by Libavius, later, it was used by chemists such as Glauber, Priestley, and Davy in their scientific research. It has numerous applications, including household cleaning, production of gelatin and other food additives, descaling. About 20 million tonnes of acid are produced worldwide annually. It is also found naturally in gastric acid, Hydrochloric acid was known to European alchemists as spirits of salt or acidum salis. Both names are used, especially in other languages, such as German, Salzsäure, Dutch, Zoutzuur, Swedish, Saltsyra, Turkish, Tuz Ruhu, Polish, kwas solny and Chinese. Gaseous HCl was called marine acid air, the old name muriatic acid has the same origin, and this name is still sometimes used. The name hydrochloric acid was coined by the French chemist Joseph Louis Gay-Lussac in 1814, aqua regia, a mixture consisting of hydrochloric and nitric acids, prepared by dissolving sal ammoniac in nitric acid, was described in the works of Pseudo-Geber, a 13th-century European alchemist. Other references suggest that the first mention of aqua regia is in Byzantine manuscripts dating to the end of the 13th century, free hydrochloric acid was first formally described in the 16th century by Libavius, who prepared it by heating salt in clay crucibles. Joseph Priestley of Leeds, England prepared pure hydrogen chloride in 1772, during the Industrial Revolution in Europe, demand for alkaline substances increased. A new industrial process developed by Nicolas Leblanc of Issoundun, France enabled cheap large-scale production of sodium carbonate, in this Leblanc process, common salt is converted to soda ash, using sulfuric acid, limestone, and coal, releasing hydrogen chloride as a by-product. Until the British Alkali Act 1863 and similar legislation in other countries, after the passage of the act, soda ash producers were obliged to absorb the waste gas in water, producing hydrochloric acid on an industrial scale. In the 20th century, the Leblanc process was replaced by the Solvay process without a hydrochloric acid by-product. Since hydrochloric acid was already settled as an important chemical in numerous applications. After the year 2000, hydrochloric acid is made by absorbing by-product hydrogen chloride from industrial organic compounds production. Hydrochloric acid is the salt of hydronium ion, H3O+ and chloride and it is usually prepared by treating HCl with water. H C l + H2 O ⟶ H3 O + + C l − Hydrochloric acid can therefore be used to prepare salts called chlorides, Hydrochloric acid is a strong acid, since it is completely dissociated in water
19.
Hydroiodic acid
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Hydroiodic acid is a highly acidic aqueous solution of hydrogen iodide. It is the strongest hydrohalic acid, hydroiodic acid is a commonly used chemical reagent and is one of the strong acids that ionize completely in an aqueous solution. Concentrated hydroiodic acid has a pH of less than 0, hydroiodic acid is currently listed as a Federal DEA List I Chemical. Owing to its usefulness as an agent, reduction with HI. Clandestine chemists react pseudoephedrine with hydroiodic acid and red phosphorus under heat, HI reacts with pseudoephedrine to form iodoephedrine, an intermediate which is reduced primarily to methamphetamine. This reaction is stereospecific, producing only -methamphetamine, due to its listed status and closely monitored sales, clandestine chemists now use red phosphorus and iodine to generate hydroiodic acid in situ. International Chemical Safety Card 1326 European Chemicals Bureau
20.
Solution
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In chemistry, a solution is a homogeneous mixture composed of two or more substances. In such a mixture, a solute is a substance dissolved in another substance, the mixing process of a solution happens at a scale where the effects of chemical polarity are involved, resulting in interactions that are specific to solvation. The solution assumes the characteristics of the solvent when the solvent is the fraction of the mixture. The concentration of a solute in a solution is the mass of that solute expressed as a percentage of the mass of the whole solution, a solution is a homogeneous mixture of two or more substances. The particles of solute in a solution cannot be seen by the naked eye, a solution does not allow beams of light to scatter. The solute from a solution cannot be separated by filtration and it is composed of only one phase. Homogeneous means that the components of the form a single phase. Heterogeneous means that the components of the mixture are of different phase, the properties of the mixture can be uniformly distributed through the volume but only in absence of diffusion phenomena or after their completion. Usually, the present in the greatest amount is considered the solvent. Solvents can be gases, liquids or solids, one or more components present in the solution other than the solvent are called solutes. The solution has the physical state as the solvent. If the solvent is a gas, only gases are dissolved under a set of conditions. An example of a solution is air. Since interactions between molecules play almost no role, dilute gases form rather trivial solutions, in part of the literature, they are not even classified as solutions, but addressed as mixtures. If the solvent is a liquid, then almost all gases, liquids, here are some examples, Gas in liquid, Oxygen in water Carbon dioxide in water – a less simple example, because the solution is accompanied by a chemical reaction. Liquid in liquid, The mixing of two or more substances of the same chemistry but different concentrations to form a constant, alcoholic beverages are basically solutions of ethanol in water. Solid in liquid, Sucrose in water Sodium chloride or any other salt in water, solutions in water are especially common. Counterexamples are provided by liquid mixtures that are not homogeneous, colloids, body fluids are examples for complex liquid solutions, containing many solutes
21.
Water
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Water is a transparent and nearly colorless chemical substance that is the main constituent of Earths streams, lakes, and oceans, and the fluids of most living organisms. Its chemical formula is H2O, meaning that its molecule contains one oxygen, Water strictly refers to the liquid state of that substance, that prevails at standard ambient temperature and pressure, but it often refers also to its solid state or its gaseous state. It also occurs in nature as snow, glaciers, ice packs and icebergs, clouds, fog, dew, aquifers, Water covers 71% of the Earths surface. It is vital for all forms of life. Only 2. 5% of this water is freshwater, and 98. 8% of that water is in ice and groundwater. Less than 0. 3% of all freshwater is in rivers, lakes, and the atmosphere, a greater quantity of water is found in the earths interior. Water on Earth moves continually through the cycle of evaporation and transpiration, condensation, precipitation. Evaporation and transpiration contribute to the precipitation over land, large amounts of water are also chemically combined or adsorbed in hydrated minerals. Safe drinking water is essential to humans and other even though it provides no calories or organic nutrients. There is a correlation between access to safe water and gross domestic product per capita. However, some observers have estimated that by 2025 more than half of the population will be facing water-based vulnerability. A report, issued in November 2009, suggests that by 2030, in developing regions of the world. Water plays an important role in the world economy, approximately 70% of the freshwater used by humans goes to agriculture. Fishing in salt and fresh water bodies is a source of food for many parts of the world. Much of long-distance trade of commodities and manufactured products is transported by boats through seas, rivers, lakes, large quantities of water, ice, and steam are used for cooling and heating, in industry and homes. Water is an excellent solvent for a variety of chemical substances, as such it is widely used in industrial processes. Water is also central to many sports and other forms of entertainment, such as swimming, pleasure boating, boat racing, surfing, sport fishing, Water is a liquid at the temperatures and pressures that are most adequate for life. Specifically, at atmospheric pressure of 1 bar, water is a liquid between the temperatures of 273.15 K and 373.15 K
22.
Polytetrafluoroethylene
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Polytetrafluoroethylene is a synthetic fluoropolymer of tetrafluoroethylene that has numerous applications. The best known name of PTFE-based formulas is Teflon by Chemours. Chemours is a spin-off of DuPont Co. which discovered the compound in 1938, PTFE is a fluorocarbon solid, as it is a high-molecular-weight compound consisting wholly of carbon and fluorine. PTFE is hydrophobic, neither water nor water-containing substances wet PTFE, PTFE has one of the lowest coefficients of friction of any solid. PTFE is used as a coating for pans and other cookware. It is very non-reactive, partly because of the strength of carbon–fluorine bonds, where used as a lubricant, PTFE reduces friction, wear and energy consumption of machinery. It is commonly used as a material in surgical interventions. Also, it is employed as coating on catheters, this interferes with the ability of bacteria and other infectious agents to adhere to catheters. PTFE was accidentally discovered in 1938 by Roy Plunkett while he was working in New Jersey for DuPont. Since Plunkett was measuring the amount of gas used by weighing the bottle, he became curious as to the source of the weight and he found the bottles interior coated with a waxy white material that was oddly slippery. Analysis showed that it was polymerized perfluoroethylene, with the iron from the inside of the container having acted as a catalyst at high pressure, Kinetic Chemicals patented the new fluorinated plastic in 1941, and registered the Teflon trademark in 1945. By 1948, DuPont, which founded Kinetic Chemicals in partnership with General Motors, was producing two million pounds of Teflon brand PTFE per year in Parkersburg, West Virginia. In 1954, the wife of French engineer Marc Grégoire urged him to try the material he had been using on fishing tackle on her cooking pans and he subsequently created the first Teflon-coated, non-stick pans under the brandname Tefal. In the United States, Marion A. Trozzolo, who had been using the substance on scientific utensils, marketed the first US-made Teflon-coated pan, The Happy Pan, however, Tefal was not the only company to utilize PTFE in nonstick cookware coatings. Other cookware companies, such as Meyer Corporations Anolon, use Teflon nonstick coatings purchased from DuPont, in the 1990s, it was found that PTFE could be radiation cross-linked above its melting point in an oxygen-free environment. Electron beam processing is one example of radiation processing, cross-linked PTFE has improved high-temperature mechanical properties and radiation stability. This was significant because, for years, irradiation at ambient conditions has been used to break down PTFE for recycling. This radiation-induced chain scission allows it to be more easily reground, PTFE is produced by free-radical polymerization of tetrafluoroethylene
23.
Fluorine
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Fluorine is a chemical element with symbol F and atomic number 9. It is the lightest halogen and exists as a highly toxic pale yellow diatomic gas at standard conditions, as the most electronegative element, it is extremely reactive, almost all other elements, including some noble gases, form compounds with fluorine. Among the elements, fluorine ranks 24th in universal abundance and 13th in terrestrial abundance, proposed as an element in 1810, fluorine proved difficult and dangerous to separate from its compounds, and several early experimenters died or sustained injuries from their attempts. Only in 1886 did French chemist Henri Moissan isolate elemental fluorine using low-temperature electrolysis, industrial production of fluorine gas for uranium enrichment, its largest application, began during the Manhattan Project in World War II. Owing to the expense of refining pure fluorine, most commercial applications use fluorine compounds, the rest of the fluorite is converted into corrosive hydrogen fluoride en route to various organic fluorides, or into cryolite which plays a key role in aluminium refining. Organic fluorides have very high chemical and thermal stability, their uses are as refrigerants, electrical insulation and cookware. Pharmaceuticals such as atorvastatin and fluoxetine also contain fluorine, and the fluoride ion inhibits dental cavities, global fluorochemical sales amount to more than US$15 billion a year. Fluorocarbon gases are generally greenhouse gases with global-warming potentials 100 to 20,000 times that of carbon dioxide, organofluorine compounds persist in the environment due to the strength of the carbon–fluorine bond. Fluorine has no metabolic role in mammals, a few plants synthesize organofluorine poisons that deter herbivores. Fluorine atoms have nine electrons, one fewer than neon, and electron configuration 1s22s22p5, the outer electrons are ineffective at nuclear shielding, and experience a high effective nuclear charge of 9 −2 =7, this affects the atoms physical properties. Fluorines first ionization energy is third-highest among all elements, behind helium and neon and it also has a high electron affinity, second only to chlorine, and tends to capture an electron to become isoelectronic with the noble gas neon, it has the highest electronegativity of any element. Fluorine atoms have a small covalent radius of around 60 picometers, similar to those of its period neighbors oxygen, conversely, bonds to other atoms are very strong because of fluorines high electronegativity. Unreactive substances like powdered steel, glass fragments, and asbestos fibers react quickly with cold fluorine gas, wood, reactions of elemental fluorine with metals require varying conditions. Some solid nonmetals react vigorously in liquid air temperature fluorine, hydrogen sulfide and sulfur dioxide combine readily with fluorine, the latter sometimes explosively, sulfuric acid exhibits much less activity, requiring elevated temperatures. Hydrogen, like some of the metals, reacts explosively with fluorine. Carbon, as black, reacts at room temperature to yield fluoromethane. Graphite combines with fluorine above 400 °C to produce non-stoichiometric carbon monofluoride, higher temperatures generate gaseous fluorocarbons, heavier halogens react readily with fluorine as does the noble gas radon, of the other noble gases, only xenon and krypton react, and only under special conditions. At room temperature, fluorine is a gas of diatomic molecules and it has a characteristic pungent odor detectable at 20 ppb
24.
Oxide
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An oxide /ˈɒksaɪd/ is a chemical compound that contains at least one oxygen atom and one other element in its chemical formula. Oxide itself is the dianion of oxygen, an O2– atom, Metal oxides thus typically contain an anion of oxygen in the oxidation state of −2. Most of the Earths crust consists of oxides, the result of elements being oxidized by the oxygen in air or in water. Hydrocarbon combustion affords the two principal carbon oxides, carbon monoxide and carbon dioxide, even materials considered pure elements often develop an oxide coating. For example, aluminium foil develops a skin of Al2O3 that protects the foil from further corrosion. Individual elements can form multiple oxides, each containing different amounts of the element. Certain elements can form many different oxides, such those of nitrogen, due to its electronegativity, oxygen forms stable chemical bonds with almost all elements to give the corresponding oxides. Noble metals are prized because they resist direct chemical combination with oxygen, two independent pathways for corrosion of elements are hydrolysis and oxidation by oxygen. The combination of water and oxygen is even more corrosive, virtually all elements burn in an atmosphere of oxygen, or an oxygen rich environment. In the presence of water and oxygen, some elements— sodium—react rapidly, even dangerously, in part for this reason, alkali and alkaline earth metals are not found in nature in their metallic, i. e. native, form. Caesium is so reactive with oxygen that it is used as a getter in vacuum tubes, the surface of most metals consists of oxides and hydroxides in the presence of air. A well-known example is aluminium foil, which is coated with a film of aluminium oxide that passivates the metal. The aluminium oxide layer can be built to greater thickness by the process of electrolytic anodising, though solid magnesium and aluminium react slowly with oxygen at STP—they, like most metals, burn in air, generating very high temperatures. Finely grained powders of most metals can be explosive in air. Consequently, they are used in Solid-fuel rockets. In dry oxygen, iron forms iron oxide, but the formation of the hydrated ferric oxides, Fe2O3−x2x. Free oxygen production by photosynthetic bacteria some 3.5 billion years ago precipitated iron out of solution in the oceans as Fe2O3 in the important iron ore hematite. Oxides have a range of different structures, from molecules to polymeric
25.
Carl Wilhelm Scheele
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Carl Wilhelm Scheele was a Swedish Pomeranian and pharmaceutical chemist. Isaac Asimov called him hard-luck Scheele because he made a number of discoveries before others who are generally given the credit. For example, Scheele discovered oxygen, and identified molybdenum, tungsten, barium, hydrogen, Scheele discovered organic acids tartaric, oxalic, uric, lactic, and citric, as well as hydrofluoric, hydrocyanic, and arsenic acids. He preferred speaking German to Swedish his whole life, as German was commonly spoken among Swedish pharmacists, Scheele was born in Stralsund, in western Pomerania, which at the time was a Swedish Dominion inside the Holy Roman Empire. Scheeles father Joachim Christian Scheele, was a dealer and brewer from a respected German family. His mother was Margaretha Eleanore Warnekros, friends of Scheeles parents taught him the art of reading prescriptions and the meaning of chemical and pharmaceutical signs. Then, in 1757, at age fourteen Carl was sent to Gothenburg as an apprentice pharmacist with another family friend, Scheele retained this position for eight years. During this time he ran experiments late into the night and read the works of Nicolas Lemery, Caspar Neumann, Johann von Löwenstern-Kunckel, much of Scheeles later theoretical speculations were based upon Stahl. Scheele arrived in Stockholm between 1767 and 1769 and worked as a pharmacist, during this period he discovered tartaric acid and with his friend, Retzius, studied the relation of quicklime to calcium carbonate. While in the capital, he became acquainted with many luminaries, such as, Abraham Bäck, Peter Jonas Bergius, Bengt Bergius. In the fall of 1770 Scheele became director of the laboratory of the pharmacy of Locke. The laboratory supplied chemicals to Professor of Chemistry Torbern Bergman, a friendship developed between Scheele and Bergman after Scheele analyzed a reaction which Bergman and his assistant Johan Gottlieb Gahn could not resolve. The reaction was between melted saltpetre and acetic acid produced a red vapor. Further study of this later led to Scheeles discovery of oxygen. Based upon this friendship and respect Scheele was given use of Bergmans laboratory. Both men were profiting from their working relationship, in 1774 Scheele was nominated by Peter Jonas Bergius to be a member of the Royal Swedish Academy of Sciences and was elected February 4,1775. In 1775 Scheele also managed for a time a pharmacy in Köping. Between the end of 1776 and the beginning of 1777 Scheele established his own business there, after his return to Köping he devoted himself, outside of his business, to scientific researches which resulted in a long series of important papers
26.
Plastic
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Plastic is a material consisting of any of a wide range of synthetic or semi-synthetic organic compounds that are malleable and can be molded into solid objects. Plastics are typically organic polymers of high mass, but they often contain other substances. They are usually synthetic, most commonly derived from petrochemicals, due to their relatively low cost, ease of manufacture, versatility, and imperviousness to water, plastics are used in an enormous and expanding range of products, from paper clips to spaceships. They have already displaced many traditional materials, such as wood, stone, horn and bone, leather, paper, metal, glass, and ceramic, in most of their former uses. In developed countries, about a third of plastic is used in packaging, other uses include automobiles, furniture, and toys. In the developing world, the ratios may be different - for example, the worlds first fully synthetic plastic was bakelite, invented in New York in 1907 by Leo Baekeland who coined the term plastics. Toward the end of the century, one approach to this problem was met with wide efforts toward recycling, the word plastic is derived from the Greek πλαστικός meaning capable of being shaped or molded, from πλαστός meaning molded. The common word plastic should not be confused with the technical adjective plastic, used for insulating parts in electrical fixtures, paper laminated products, thermally insulation foams. Problems include the probability of moldings naturally being dark colors, One of the most expensive commercial polymers. It forms the basis of artistic and commercial acrylic paints when suspended in water with the use of other agents, polytetrafluoroethylene – Heat-resistant, low-friction coatings, used in things like non-stick surfaces for frying pans, plumbers tape and water slides. It is more known as Teflon. Urea-formaldehyde – One of the aminoplasts and used as an alternative to phenolics. Used as an adhesive and electrical switch housings. Early plastics were bio-derived materials such as egg and blood proteins, in 1600 BC, Mesoamericans used natural rubber for balls, bands, and figurines. Treated cattle horns were used as windows for lanterns in the Middle Ages, materials that mimicked the properties of horns were developed by treating milk-proteins with lye. In the 1800s, as industrial chemistry developed during the Industrial Revolution, the development of plastics also accelerated with Charles Goodyears discovery of vulcanization to thermoset materials derived from natural rubber. Parkesine is considered the first man-made plastic, the plastic material was patented by Alexander Parkes, In Birmingham, UK in 1856. It was unveiled at the 1862 Great International Exhibition in London, parkesine won a bronze medal at the 1862 Worlds fair in London
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Ionization
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Ionization is the process by which an atom or a molecule acquires a negative or positive charge by gaining or losing electrons to form ions, often in conjunction with other chemical changes. Ionization can result from the loss of an electron after collisions with particles, collisions with other atoms, molecules and ions. Heterolytic bond cleavage and heterolytic substitution reactions can result in the formation of ion pairs, ionization can occur through radioactive decay by the internal conversion process, in which an excited nucleus transfers its energy to one of the inner-shell electrons causing it to be ejected. Everyday examples of gas ionization are such as within a fluorescent lamp or other electrical discharge lamps and it is also used in radiation detectors such as the Geiger-Müller counter or the ionization chamber. The ionization process is used in a variety of equipment in fundamental science and in such as mass spectrometry. Negatively charged ions are produced when an electron collides with an atom and is subsequently trapped inside the electric potential barrier. The process is known as electron capture ionization, positively charged ions are produced by transferring a sufficient amount of energy to a bound electron in a collision with charged particles or with photons. The threshold amount of the energy is known as ionization potential. The study of such collisions is of importance with regard to the few-body problem. The Townsend discharge is an example of the creation of positive ions. It is a reaction involving electrons in a region with a sufficiently high electric field in a gaseous medium that can be ionized. Following an original event, due to such as ionizing radiation. If the electric field is strong enough, the free electron gains sufficient energy to liberate a further electron when it collides with another molecule. The two free electrons then travel towards the anode and gain sufficient energy from the field to cause impact ionization when the next collisions occur. This is effectively a chain reaction of electron generation, and is dependent on the free electrons gaining sufficient energy between collisions to sustain the avalanche, ionization efficiency is the ratio of the number of ions formed to the number of electrons or photons used. The trend in the energy of atoms is often used to demonstrate the periodic behavior of atoms with respect to the atomic number. This is a tool for establishing and understanding the ordering of electrons in atomic orbitals without going into the details of wave functions or the ionization process. An example is presented in figure 1, the periodic abrupt decrease in ionization potential after rare gas atoms, for instance, indicates the emergence of a new shell in alkali metals
28.
Hydrogen halide
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Hydrogen halides are diatomic inorganic compounds with the formula HX where X is one of the halogens, fluorine, chlorine, bromine, iodine, or astatine. Hydrogen halides are gases that dissolve in water to give acids which are known as hydrohalic acids. The hydrogen halides are diatomic molecules with no tendency to ionize in the gas phase, thus, chemists distinguish hydrogen chloride from hydrochloric acid. The former is a gas at room temperature that reacts with water to give the acid, once the acid has formed, the diatomic molecule can be regenerated only with difficulty, but not by normal distillation. Commonly the names of the acid and the molecules are not clearly distinguished such that in lab jargon, HCl often means hydrochloric acid, hydrogen chloride, in the form of hydrochloric acid, is a major component of gastric acid. Hydrogen fluoride, chloride and bromide are also volcanic gases, the direct reaction of hydrogen with fluorine and chlorine gives hydrogen fluoride and hydrogen chloride, respectively. Industrially these gases are, however, produced by treatment of halide salts with sulfuric acid, hydrogen bromide arises when hydrogen and bromine are combined at high temperatures in the presence of a platinum catalyst. The least stable hydrogen halide, HI, is produced less directly, the hydrogen halides are colourless gases at Standard Temperature and Pressure except for hydrogen fluoride, which boils at 19 °C. Alone of the halides, hydrogen fluoride exhibits hydrogen bonding between molecules, and therefore has the highest melting and boiling points of the HX series. From HCl to HI the boiling point rises and this trend is attributed to the increasing strength of intermolecular van der Waals forces, which correlates with numbers of electrons in the molecules. Concentrated hydrohalic acid solutions produce visible white fumes and this mist arises from the formation of tiny droplets of their concentrated aqueous solutions of the hydrohalic acid. Upon dissolution in water, which is exothermic, the hydrogen halides give the corresponding acids. These acids are strong, reflecting their tendency to ionize in aqueous solution yielding hydronium ions. With the exception of hydrofluoric acid, the halides are strong acids. Hydrofluoric acid is complicated because its strength depends on the concentration owing to the effects of homoconjugation, as solutions in non-aqueous solvents, such as acetonitrile, the hydrogen halides are only modestly acidic however. Similarly, the hydrogen halides react with ammonia, forming ammonium halides, HX + NH3 → NH4X In organic chemistry, for example, chloroethane is produced by hydrochlorination of ethylene, C2H4 + HCl → CH3CH2Cl Pseudohalogen
29.
Acid strength
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The strength of an acid refers to its ability or tendency to lose a proton. A strong acid is one that completely ionizes in a solution, in water, one mole of a strong acid HA dissolves yielding one mole of H+ and one mole of the conjugate base, A−. Essentially, none of the non-ionized acid HA remains. Examples of strong acids are hydrochloric acid, hydroiodic acid, hydrobromic acid, perchloric acid, nitric acid, in aqueous solution, each of these essentially ionizes 100%. In contrast, an acid only partially dissociates. Examples in water include carbonic acid and acetic acid, at equilibrium, both the acid and the conjugate base are present in solution. Stronger acids have an acid dissociation constant and a smaller logarithmic constant than weaker acids. The stronger an acid is, the more easily it loses a proton, two key factors that contribute to the ease of deprotonation are the polarity of the H—A bond and the size of atom A, which determines the strength of the H—A bond. Acid strengths also depend on the stability of the conjugate base, while Ka measures the strength of an acidic molecule, the strength of an aqueous acid solution is measured by pH, which is a function of the concentration of hydronium ions in solution. The pH of a solution of an acid in water is determined by both Ka and the acid concentration. For weak acid solutions, it depends on the degree of dissociation, for concentrated solutions of strong acids with a pH less than about zero, the Hammett acidity function is a better measure of acidity than the pH. Sulfonic acids, which are organic oxyacids, are a class of strong acids, a common example is p-toluenesulfonic acid. Unlike sulfuric acid itself, sulfonic acids can be solids, in fact, polystyrene functionalized into polystyrene sulfonate is a solid strongly acidic plastic that is filterable. Superacids are acid solutions that are more acidic than 100% sulfuric acid, examples of superacids are fluoroantimonic acid, magic acid and perchloric acid. Superacids can permanently protonate water to give ionic, crystalline hydronium salts and they can also quantitatively stabilize carbocations. In aqueous solution, an acid is an acid that ionizes completely by losing one proton.74. An example is HCl for which pKa = −6.3 and this generally means that, in aqueous solution at standard temperature and pressure, the concentration of hydronium ions is equal to the concentration of strong acid introduced to the solution. No acid species stronger than H3O+ can exist in aqueous solution, the acidity of the stronger acid is said to be leveled to the acidity of hydronium ion. Strong acids are distinguished from weak acids, in which dissociation is incomplete and is represented as an equilibrium, the typical definition of a weak acid is any acid that does not dissociate completely
30.
Bifluoride
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Bifluoride is an inorganic anion with the chemical formula HF−2. It contributes no color to bifluoride salts, salts of bifluoride are used to etch glass. Bifluoride undergoes the chemical reactions of a weak acid. Upon treatment with an acid, it converts to hydrofluoric acid. Its conjugate acid is the intermediate, μ-fluoro-fluorodihydrogen, which subsequently dissociates to become hydrogen fluoride. In solution, most bifluoride ions are dissociated, a molecular orbital diagram reveals the atoms to be held together by a 3-center 4-electron bond. It is isoelectronic with the anion, FHeO−, whose existence is suspected. Hydrogen is written as one word because it is a unified anion, some HF2− salts are common, examples include potassium bifluoride and ammonium bifluoride. Many salts claimed to be sources of simple fluoride ions, for example, tetra-n-butylammonium fluoride. The bifluoride ion also contributes to the unusually high auto-protolysis constant of liquid hydrogen fluoride. This equilibrium can be denoted as HF ⇌ H+ + F− However, both the H+ and F− ions are solvated by HF, so a better descriptive equation is 3HF ⇌ H2F+ + HF2−
31.
Hydrogen bond
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Hydrogen bonds can occur between molecules or within different parts of a single molecule. Depending on geometry and environment, the hydrogen bond free energy content is between 1 and 5 kcal/mol and this makes it stronger than a van der Waals interaction, but weaker than covalent or ionic bonds. This type of bond can occur in molecules such as water and in organic molecules like DNA. Intermolecular hydrogen bonding is responsible for the boiling point of water compared to the other group 16 hydrides that have much weaker hydrogen bonds. Intramolecular hydrogen bonding is responsible for the secondary and tertiary structures of proteins. It also plays an important role in the structure of polymers, in 2011, an IUPAC Task Group recommended a modern evidence-based definition of hydrogen bonding, which was published in the IUPAC journal Pure and Applied Chemistry. An accompanying detailed technical report provides the rationale behind the new definition, a hydrogen atom attached to a relatively electronegative atom will play the role of the hydrogen bond donor. This electronegative atom is usually fluorine, oxygen, or nitrogen, a hydrogen attached to carbon can also participate in hydrogen bonding when the carbon atom is bound to electronegative atoms, as is the case in chloroform, CHCl3. An example of a hydrogen donor is the hydrogen from the hydroxyl group of ethanol. In a hydrogen bond, the electronegative atom not covalently attached to the hydrogen is named proton acceptor, because of the small size of hydrogen relative to other atoms and molecules, the resulting charge, though only partial, represents a large charge density. A hydrogen bond results when this positive charge density attracts a lone pair of electrons on another heteroatom. The hydrogen bond is described as an electrostatic dipole-dipole interaction. These covalent features are more substantial when acceptors bind hydrogens from more electronegative donors, the partially covalent nature of a hydrogen bond raises the following questions, To which molecule or atom does the hydrogen nucleus belong. And Which should be labeled donor and which acceptor, liquids that display hydrogen bonding are called associated liquids. Hydrogen bonds can vary in strength from weak to extremely strong. For example, the central interresidue N−H···N hydrogen bond between guanine and cytosine is much stronger in comparison to the N−H···N bond between the adenine-thymine pair, the length of hydrogen bonds depends on bond strength, temperature, and pressure. The bond strength itself is dependent on temperature, pressure, bond angle, the typical length of a hydrogen bond in water is 197 pm. The ideal bond angle depends on the nature of the hydrogen bond donor, moore and Winmill used the hydrogen bond to account for the fact that trimethylammonium hydroxide is a weaker base than tetramethylammonium hydroxide
32.
Fluorite
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Fluorite is the mineral form of calcium fluoride, CaF2. It belongs to the halide minerals and it crystallizes in isometric cubic habit, although octahedral and more complex isometric forms are not uncommon. Mohs scale of hardness, based on scratch Hardness comparison. Fluorite is a mineral, both in visible and ultraviolet light, and the stone has ornamental and lapidary uses. Industrially, fluorite is used as a flux for smelting, and in the production of certain glasses, the purest grades of fluorite are a source of fluoride for hydrofluoric acid manufacture, which is the intermediate source of most fluorine-containing fine chemicals. Optically clear transparent fluorite lenses have low dispersion, so made from it exhibit less chromatic aberration. Fluorite optics are also usable in the range, where conventional glasses are too absorbent for use. The word fluorite is derived from the Latin verb fluere, meaning to flow, the mineral is used as a flux in iron smelting to decrease the viscosity of slags. The term flux comes from the Latin adjective fluxus, meaning flowing, loose, agricola, a German scientist with expertise in philology, mining, and metallurgy, named fluorspar as a neo-Latinization of the German Flussspat from Fluß and Spat. In 1852, fluorite gave its name to the phenomenon of fluorescence, Fluorite also gave the name to its constitutive element fluorine. Presently, the fluorspar is most commonly used for fluorite as the industrial and chemical commodity, while fluorite is used mineralogically. Fluorite crystallises in a cubic motif, crystal twinning is common and adds complexity to the observed crystal habits. Fluorite has four perfect cleavage planes that help produce octahedral fragments, element substitution for the calcium cation often includes certain rare earth elements, such as yttrium and cerium. Iron, sodium, and barium are also common impurities, some fluorine may be replaced by the chloride anion. Fluorite is a widely occurring mineral that occurs globally with significant deposits in over 9,000 areas. It may occur as a deposit, especially with metallic minerals, where it often forms a part of the gangue and may be associated with galena, sphalerite, barite, quartz. It is a mineral in deposits of hydrothermal origin and has been noted as a primary mineral in granites and other igneous rocks. The world reserves of fluorite are estimated at 230 million tonnes with the largest deposits being in South Africa, Mexico, China is leading the world production with about 3 Mt annually, followed by Mexico, Mongolia, Russia, South Africa, Spain and Namibia
33.
Sulfuric acid
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Sulfuric acid is a highly corrosive strong mineral acid with the molecular formula H2SO4 and molecular weight 98.079 g/mol. It is a pungent-ethereal, colorless to slightly yellow liquid that is soluble in water at all concentrations. Sometimes, it is dyed dark brown during production to alert people to its hazards, the historical name of this acid is oil of vitriol. Sulfuric acid is an acid and shows different properties depending upon its concentration. Its corrosiveness on other materials, like metals, living tissues or even stones, can be ascribed to its strong acidic nature and, if concentrated. It is also hygroscopic, readily absorbing water vapour from the air, Sulfuric acid at a high concentration can cause very serious damage upon contact, since not only does it cause chemical burns via hydrolysis, but also secondary thermal burns through dehydration. It can lead to permanent blindness if splashed onto eyes and irreversible damage if swallowed, Sulfuric acid has a wide range of applications including in domestic acidic drain cleaners, as an electrolyte in lead-acid batteries and in various cleaning agents. It is also a central substance in the chemical industry, principal uses include mineral processing, fertilizer manufacturing, oil refining, wastewater processing, and chemical synthesis. It is widely produced with different methods, such as process, wet sulfuric acid process, lead chamber process. The study of vitriol, a category of glassy minerals from which the acid can be derived, sumerians had a list of types of vitriol that they classified according to the substances color. Some of the earliest discussions on the origin and properties of vitriol is in the works of the Greek physician Dioscorides, galen also discussed its medical use. Ibn Sina focused on its uses and different varieties of vitriol. Sulfuric acid was called oil of vitriol by medieval European alchemists because it was prepared by roasting green vitriol in an iron retort, there are references to it in the works of Vincent of Beauvais and in the Compositum de Compositis ascribed to Saint Albertus Magnus. A passage from Pseudo-Geber´s Summa Perfectionis was long considered to be the first recipe for sulfuric acid, in the seventeenth century, the German-Dutch chemist Johann Glauber prepared sulfuric acid by burning sulfur together with saltpeter, in the presence of steam. As saltpeter decomposes, it oxidizes the sulfur to SO3, in 1736, Joshua Ward, a London pharmacist, used this method to begin the first large-scale production of sulfuric acid. This process allowed the effective industrialization of sulfuric acid production, after several refinements, this method, called the lead chamber process or chamber process, remained the standard for sulfuric acid production for almost two centuries. Sulfuric acid created by John Roebucks process approached a 65% concentration, later refinements to the lead chamber process by French chemist Joseph Louis Gay-Lussac and British chemist John Glover improved concentration to 78%. However, the manufacture of dyes and other chemical processes require a more concentrated product
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Calcium sulfate
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Calcium sulfate is the inorganic compound with the formula CaSO4 and related hydrates. In the form of γ-anhydrite, it is used as a desiccant, one particular hydrate is better known as plaster of Paris, and another occurs naturally as the mineral gypsum. It has many uses in industry, all forms are white solids that are poorly soluble in water. Calcium sulfate causes permanent hardness in water, the compound exists in three levels of hydration, anhydrous state with the formula CaSO4. Specific hemihydrates are sometimes distinguished, alpha-hemihydrate and beta-hemihydrate, the main use of calcium sulfate is to produce Plaster of Paris and stucco. These applications exploit the fact that calcium sulfate forms a moldable paste upon hydration and it is also convenient that calcium sulfate is very poorly soluble in water, so structures do not dissolve. Temperatures between 100 °C and 150 °C are required to drive off the water within its structure, the details of the temperature and time depend on ambient humidity. Temperatures as high as 170 °C are used in industrial calcination, in a fire, the structure behind a sheet of drywall will remain relatively cool as water is lost from the gypsum, thus preventing damage to the framing and consequent structural collapse. But at higher temperatures, calcium sulfate will release oxygen and act as an oxidizing agent and this property is used in aluminothermy. Mixed with polymers, it has used as a bone repair cement. Small amounts of calcined gypsum are added to earth to create strong structures directly from cast earth, the conditions of dehydration can be changed to adjust the porosity of the hemihydrate, resulting in the so-called alpha and beta hemihydrates. On heating to 180 °C, the nearly water-free form, called γ-anhydrite is produced, γ-Anhydrite reacts slowly with water to return to the dihydrate state, a property exploited in some commercial desiccants. On heating above 250 °C, the anhydrous form called β-anhydrite or natural anhydrite is formed. Natural anhydrite does not react with water, even over geological timescales, the hydrates are used as a coagulant in products such as tofu. Up to the 1970s, commercial quantities of sulfuric acid were produced from the anhydride of calcium sulfate, when sold as a color-indicating variant under the name Drierite, it appears blue or pink due to impregnation with cobalt chloride, which functions as a moisture indicator. The main sources of sulfate are naturally occurring gypsum and anhydrite. These may be extracted by open-cast quarrying or by deep mining, world production of natural gypsum is around 127 million tonnes per annum. This produces an impure calcium sulfite, which oxidizes on storage to calcium sulfate, in the production of phosphoric acid from phosphate rock, calcium phosphate is treated with sulfuric acid and calcium sulfate precipitates
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Chemical equation
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The coefficients next to the symbols and formulae of entities are the absolute values of the stoichiometric numbers. The first chemical equation was diagrammed by Jean Beguin in 1615, a chemical equation consists of the chemical formulas of the reactants and the chemical formula of the products. The two are separated by a symbol and each individual substances chemical formula is separated from others by a plus sign. But, for equations involving complex chemicals, rather than reading the letter and its subscript, using IUPAC nomenclature, this equation would be read as hydrochloric acid plus sodium yields sodium chloride and hydrogen gas. This equation indicates that sodium and HCl react to form NaCl, the stoichiometric coefficients result from the law of conservation of mass and the law of conservation of charge. Symbols are used to differentiate different types of reactions. To denote the type of reaction, = symbol is used to denote a stoichiometric relation, → symbol is used to denote a net forward reaction. ⇄ symbol is used to denote a reaction in both directions, ⇌ symbol is used to denote an equilibrium. The physical state of chemicals is very commonly stated in parentheses after the chemical symbol. When stating physical state, denotes a solid, denotes a liquid, denotes a gas, if the reaction requires energy, it is indicated above the arrow. A capital Greek letter delta is put on the arrow to show that energy in the form of heat is added to the reaction. H ν is used if the energy is added in the form of light, other symbols are used for other specific types of energy or radiation. The law of conservation of mass dictates that the quantity of each element does not change in a chemical reaction, thus, each side of the chemical equation must represent the same quantity of any particular element. Likewise, the charge is conserved in a chemical reaction, therefore, the same charge must be present on both sides of the balanced equation. One balances a chemical equation by changing the number for each chemical formula. Simple chemical equations can be balanced by inspection, that is, by trial, another technique involves solving a system of linear equations. Balanced equations are written with smallest whole-number coefficients, if there is no coefficient before a chemical formula, the coefficient 1 is understood. Looking at the atom, the right-hand side has two atoms, while the left-hand side has four
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