Hypoxia-inducible factor
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Hypoxia-inducible factors are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They also respond to instances of pseudohypoxia, such as thia
Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex.
Structure of hypoxia-inducible factor-1 alpha subunit.
Gregg L. Semenza
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Gregg Leonard Semenza is an American pediatrician and Professor of Genetic Medicine at the Johns Hopkins School of Medicine. He serves as the director of the vascular program at the Institute for Cell
Hypoxia-inducible factor
…pseudohypoxia leads to impairment of adenosine triphosphate (ATP) production by the mitochondria. The HIF transcriptional complex was discovered in 1995 by Gregg L. Semenza and postdoctoral fellow Guang Wang. In 2016, William Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza were presented the Lasker Award for their work…
Semenza in Stockholm, December, 2019