The IBM System/390 is a discontinued mainframe product family implementing ESA/390, the fifth generation of the System/360 instruction set architecture. The first computers to use the ESA/390 were the Enterprise System/9000 (ES/9000) family, which were introduced in 1990. These were followed by the 9672, Multiprise, and Integrated Server families of System/390 in 1994–1999, using CMOS microprocessors. The ESA/390 succeeded ESA/370, used in the Enhanced 3090 and 4381 "E" models, and the System/370 architecture last used in the IBM 9370 low-end mainframe. ESA/390 was succeeded by the 64-bit z/Architecture in 2000.

IBM Z is a family name used by IBM for all of its z/Architecture mainframe computers. In July 2017, with another generation of products, the official family was changed to IBM Z from IBM z Systems; the IBM Z family now includes the newest model, the IBM z16, as well as the z15, the z14, and the z13, the IBM zEnterprise models, the IBM System z10 models, the IBM System z9 models and IBM eServer zSeries models.