Illinois Route 14 is a major east–west highway in southern Illinois. It runs from U.S. Route 51 south of Du Quoin to the New Harmony Toll Bridge over the Wabash River to State Road 66 at the Indiana state line. This is a distance of 76.24 miles (122.70 km).

U.S. Route 460 (US 460) is an auxiliary route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route U.S. Route 60 at Ocean View to Frankfort, Kentucky, intersecting its parent route once again. It passes through the states of Virginia, West Virginia, and Kentucky. It goes through the cities and towns of Norfolk, Portsmouth, Suffolk, Petersburg, Farmville, Lynchburg, Roanoke, Christiansburg, Blacksburg, Tazewell, and Grundy, in Virginia; Princeton and Bluefield in West Virginia; and Pikeville, Georgetown, and Frankfort in Kentucky.