Illinois Route 14 is a major east–west highway in southern Illinois. It runs from U.S. Route 51 south of Du Quoin to the New Harmony Toll Bridge over the Wabash River to State Road 66 at the Indiana state line. This is a distance of 76.24 miles (122.70 km).

The New Harmony Toll Bridge, also known as the Harmony Way Bridge, is a now-closed two-lane bridge across the Wabash River that connects Illinois Route 14 with Indiana State Road 66, which is Church Street in New Harmony, Indiana. The bridge links White County, Illinois with Posey County, Indiana and carried U.S. Route 460 from 1947 until 1974 when the highway was decommissioned in Illinois and Indiana. The four-span bridge is owned by the White County Bridge Commission and was built without federal funds in 1930 by the Big Wabash Bridge Company of Carmi, Illinois. The next bridge across the Wabash about 15 miles (24 km) downstream is the Wabash Memorial Bridge near Mount Vernon, Indiana and the next bridge upstream is for Interstate 64, which does not allow farm vehicles.