Illinois Route 50 (IL 50) is a 66.49-mile-long (107.01 km) north–south state highway in northeastern Illinois. It runs from the junction with U.S. Route 45 (US 45) and U.S. Route 52 (US 52) in West Kankakee north to US 41 in Skokie. In Chicago and the suburbs it's known as Cicero Avenue. Before this, Cicero Avenue was previously known as 48th Avenue, owing to its City of Chicago address of 4800 West.

U.S. Route 52 (US 52) in the state of Illinois, is a surface road that traverses the north central and eastern portions of the state. It runs from the Dale Gardner Veterans Memorial Bridge over the Mississippi River between Sabula, Iowa, and Savanna with Illinois Route 64 (IL 64) southeast to the Indiana state line near Sheldon with US 24. This is a distance of 215.78 miles (347.26 km).