The doctrine of the Imamate in Isma'ilism differs from that of the Twelvers because the Isma'ilis had living Imams for centuries after the last Twelver Imam went into concealment. They followed Isma'il ibn Ja'far, elder brother of Musa al-Kadhim, as the rightful Imam after his father, Ja'far al-Sadiq. The Ismailis believe that whether Imam Ismail did or did not die before Imam Ja'far, he had passed on the mantle of the imamate to his son Muhammad ibn Isma'il as the next imam.

Twelver Shīʿism, also known as Imāmiyya, is the largest branch of Shīʿa Islam, comprising about 85 percent of all Shīʿa Muslims. The term Twelver refers to its adherents' belief in twelve divinely ordained leaders, known as the Twelve Imams, and their belief that the last Imam, Imam al-Mahdi, lives in Occultation and will reappear as the promised Mahdi.