In the Bedroom is a 2001 American independent crime film directed by Todd Field from a screenplay written by Field and Robert Festinger, based on the short story "Killings" by Andre Dubus. It stars Sissy Spacek, Tom Wilkinson, Nick Stahl, Marisa Tomei, William Mapother; the film centers on the inner dynamics of a family in transition. Matt Fowler is married to Ruth Fowler, a music teacher, their son Frank is involved in a love affair with Natalie Strout. As the beauty of Maine's brief and fleeting summer comes to an end, these characters find themselves in the midst of an unimaginable tragedy; the title refers to the rear compartment of a lobster trap known as the "bedroom" and the fact that it can only hold up to two lobsters before they begin to turn on each other. In the Bedroom premiered at the Sundance Film Festival, it was theatrically released in limited theatres on November 23, 2001 and grossed $43.4 million against a $1.7 million budget. The film was praised. In the Bedroom was chosen by the American Film Institute as one of the top 10 films of the year while Spacek's performance was named the best female performance of the year.

The film received five Oscar nominations at the 74th Academy Awards: Best Picture, Best Actress, Best Actor, Best Supporting Actress, Best Adapted Screenplay, three nominations at the 59th Golden Globe Awards including for the Best Motion Picture – Drama, winning Best Actress – Drama. In the Mid-Coast town of Camden, Maine and Ruth Fowler enjoy a happy marriage and a good relationship with their son Frank, a recent college graduate who has come home for the summer. Frank has fallen in love with an older woman with Natalie Strout. Frank is about to begin post graduate school for architecture, but is having second thoughts and considering staying in town to continue working as a fisherman and, more to be near Natalie. Natalie's ex-husband, Richard Strout, tries to find a way into his ex-wife and children's lives, going to violent lengths to get his intentions across to Natalie. Ruth is concerned about Frank's relationship with Natalie, while Matt thinks it is only a fling. Richard kills Frank during a confrontation at Natalie's house following a domestic dispute.

Though devastated and Ruth grieve in different ways, with Matt putting on a brave face while Ruth becomes reclusive and quiet. Richard is set free on bail, paid by his well-to-do family, both Matt and Ruth are forced to see Richard around town; the tension between Matt and Ruth increases when they learn that the lack of an eyewitness to Frank's shooting means Richard will instead be charged with accidental manslaughter. An argument erupts between the couple. With the air cleared, the couple is able to find common ground in their grief. Matt abducts and kills Richard, he and a friend bury the body on the friend's wooded property. Matt returns home to Ruth, awake and smoking in bed, she asks him, "Did you do it?" Matt appears unresponsive. He climbs into bed and turns away from her. Ruth gets up to make coffee. Matt pulls a band-aid from a finger he injured hauling traps. Ruth calls from the kitchen, "Matt, do you want coffee?" Matt doesn't answer. Sissy Spacek as Ruth Fowler Tom Wilkinson as Matt Fowler Nick Stahl as Frank Fowler Marisa Tomei as Natalie Strout William Mapother as Richard Strout Celia Weston as Katie Grinnel Karen Allen as Marla Keyes William Wise as Willis Grinnel Justin Ashforth as Tim Bryson Camden Munson as Jason Strout Frank T.

Wells as Henry Upon its release, the film received positive responses for its direction and performances, notably Wilkinson and Spacek. On Rotten Tomatoes the film has a "certified fresh" approval rating of 93% based on 137 reviews, with an average score of 7.9/10. The site's consensus states "Expertly crafted and performed, In the Bedroom is a wrenching portrayal of grief." On Metacritic the film has a score of 86 out of 100 based on reviews from 31 critics, indicating "universal acclaim". David Edelstein of Slate Magazine wrote on his review that it is the "best movie of the last several years" and described it "the most evocative, the most mysterious, the most inconsolably devastating" film, he further mentioned that the effect of the film "isn't over when you leave the theater" and that it's "always going to be there". He called In the Bedroom a "masterpiece". Neil Norman of The Evening Standard stated that "... Field has not only studied the masters of cinematic understatement, such as Ozu and Bergman, but that he understands their processes...

Field's achievement is such a consummated marriage of intent and execution that he need never make another movie. I would not be alone, I think, in hoping he will make many more."William Arnold of the Seattle Post-Intelligencer compared Field's direction to Kubrick's, saying that it "manages to feel both controlled and effortlessly spontaneous at the same time. He further mentioned that "like Kubrick, Field doesn't make any moral judgments about his characters, his film remains stubbornly enigmatic, it can be read as a high-class revenge thriller, an ode to the futility of vengeance or anything in between."Roger Ebert of the Chicago Sun-Times stated on his review that it is "one of the best-directed films of the year" and that "every performance has a perfect tone

The Department of Zoology, founded in 1860, is a science department in the University of Oxford’s Mathematical and Life Sciences Division. The Department of Zoology is recognised internationally for its research on ecological and evolutionary biology; this research spans all levels from molecules to ecosystems, tackles fundamental problems in disease biology, evolutionary mechanisms, conservation biology, evolutionary developmental biology and animal behaviour. This diversity is echoed in teaching: the Department of Zoology and Department of Plant Sciences jointly deliver a broad-ranging and regarded undergraduate degree in Biology. Within its broad research portfolio, the Department incorporates several research institutes such as the Edward Grey Institute of Field Ornithology, the Wildlife Conservation Research Unit; the Department of Zoology has 60 academic staff and research fellows. It houses large groups of post doctoral researchers and graduate students. External research income to the Department is derived from over 50 different funding agencies, with the principal funders over the period 2015-2020 being the European Research Council, the Royal Society, the Wellcome Trust, NERC and BBSRC.

Recent success with the prestigious European Research Council is substantial. The Department of Zoology proudly holds an Athena SWAN Bronze Award, we are keen to recognise advancement of gender equality: representation and success for all. Equality and inclusion is at the core of our communication strategy, our engaged community of early career researchers hold seminars and social events to bring together all members of the Department. Many distinguished scientists have worked in the Department at various stages in their careers, including three Nobel Laureates, three winners of the Crafoord Prize, the Kyoto Prize and Blue Planet Prize, as well as four winners of the Copley Medal. Members of the department have a distinguished record of public service in the sciences, including the Presidentship of The Royal Society, with numerous honours awarded to reflect this service; the Department of Zoology carries out research on a broad range of topics, though with an emphasis on problems involving how organisms evolve and interact with their environment.

We organise our research into four broad themes: Behaviour Animal Behaviour research in Oxford has a long and distinguished history, beginning with the arrival of Niko Tinbergen in 1949. Since research from both mechanistic and evolutionary standpoints has flourished, with the work of Richard Dawkins, Bill Hamilton and Marian Dawkins; the Department played a pivotal role in the development of the field of Behavioural Ecology, with John Krebs and Nick Davies co-authoring the book that defined the field. Current behavioural research employs a wide range of approaches from field and laboratory studies, from theoretical modelling via biomimetics to applied animal welfare research research. A wide range of organisms are studied from bacteria to vertebrates. Ecology and Conservation Research in the Department of Zoology played a major role in the emergence of modern ecology through the work of figures such as Charles Elton, David Lack, Richard Southwood and Robert May. Current ecological research in the Zoology Department includes field studies, laboratory experiments and theoretical modelling, involves organisms that range from birds and mammals through insects and plants to bacteria and viruses.

It addresses both fundamental questions, as well as important issues in population management and conservation. Evolution and Development The study of Evolution has a long and distinguished history in Oxford, beginning with Ray Lankester in the 1890s and thriving through the twentieth century with work on kin selection and the selfish gene by Bill Hamilton and Richard Dawkins, development of the ‘comparative method’ by Paul Harvey and others. Current evolutionary biology research uses field and laboratory studies, experimental evolution and genome analyses on a range of organisms including viruses, yeast and animals. Developmental Biology has a long history, from J. W. Jenkinson a century ago, through research into cellular reprogramming by John Gurdon, the early transgenic work of Frank Constantini and Elizabeth Lacy, hosting of the ICRF Developmental Biology Unit in the 1990s. Current developmental biology research includes studies on evolutionary developmental biology and the cell cycle.

Infectious Disease The Zoology Department houses a number of research groups working on the ecology and evolution of infectious diseases. The topics explored range from pathogen life-history strategies and corresponding host defences to the interaction of hosts and pathogens at a community level. We continue the tradition, initiated by Robert May, of using mathematical modelling techniques to understand these complex systems, have a strong representation in laboratory and field research. There is an emphasis, in most cases, on disease control as well as progress in basic biology; the modular structure of the Oxford Biology course encourages a cross-disciplinary approach. The options system in t

Félix Sarriugarte Montoya is a Spanish retired footballer who played as a forward, an assistant coach for American club Charlotte Independence. Born in Durango, Sarriugarte represented Athletic Bilbao for five seasons – having arrived at the club at age 16 – but only started featuring for the first team in 1986–87, after appearing in 99 games for the reserves and scoring 29 goals, he spent another five years in La Liga with Asturias' Real Oviedo, where he was never relegated. Sarriugarte retired in 1996 at the age of 31 after playing one season with UD Las Palmas and splitting his last year with local Barakaldo CF and UDA Gramenet, with all the sides competing in the lower leagues. In the top flight, he amassed totals of 28 goals. Sarriugarte took up coaching in the early 2000s, with the various sides of his first club Athletic. On 8 July 2006, following the dismissal of Javier Clemente, he was appointed first-team manager by president Fernando Lamikiz. In June 2009, Sarriugarte signed at CD Varea, freshly promoted to Segunda División B, but stepped down before the campaign began.

On 16 July 2012, after having led Sestao River Club to safety in that level, he joined another team in the same tier, Oviedo. Charlotte Independence announced on 17 January 2019 that Sarriugarte had joined the technical staff of the club as an assistant manager, under Jim McGuinness. Félix Sarriugarte at BDFutbol Félix Sarriugarte manager profile at BDFutbol Félix Sarriugarte at Athletic Bilbao

Lymphocytic choriomeningitis is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is lymphocytic choriomeningitis mammarenavirus, a member of the family Arenaviridae; the name was coined by Charles Armstrong in 1934. Lymphocytic choriomeningitis is "a viral infection of the membranes surrounding the brain and spinal cord and of the cerebrospinal fluid"; the name is based on the tendency of an individual to have abnormally high levels of lymphocytes during infection. Choriomeningitis is "cerebral meningitis in which there is marked cellular infiltration of the meninges with a lymphocytic infiltration of the choroid plexuses". LCMV infection manifests itself in a wide range of clinical symptoms, may be asymptomatic for immunocompetent individuals. Onset occurs between one or two weeks after exposure to the virus and is followed by a biphasic febrile illness. During the initial or prodromal phase, which may last up to a week, common symptoms include fever, lack of appetite, muscle aches, nausea, and/or vomiting.

Less frequent symptoms include a sore throat and cough, as well as joint and parotid pain. The onset of the second phase occurs several days after recovery, consists of symptoms of meningitis or encephalitis. Pathological findings during the first stage consist of thrombocytopenia. During the second phase, typical findings include elevated protein levels, increased leukocyte count, or a decrease in glucose levels of the cerebrospinal fluid). A patient improves for a few days relapses with aseptic meningitis, or rarely, meningoencephalitis. Patients with meningitis may have a stiff neck, headache, myalgia and malaise. In some occasions, meningitis occurs without a prodromal syndrome. Meningoencephalitis is characterized by more profound neurological signs such as confusion, sensory abnormalities and motor signs. Under reported complications include myelitis, Guillain–Barré-type syndrome, cranial nerve palsies, transient or permanent hydrocephalus, sensorineural hearing loss, orchitis and parotitis.

LCMV infections have been associated with pancreatitis, pneumonitis and pericarditis. The entire illness lasts 1 to 3 weeks, temporary or permanent neurological damage is possible in all central nervous system infections in cases of meningoencephalitis. Chronic infections have not been reported in humans and deaths occur. There are several strains of LCM virus, among which the most used are LCMV Armstrong and LCMV Clone 13. Armstrong is the original virus strain, isolated from the brain by Charles Armstrong in 1934, it triggers a vigorous cytotoxic T lymphocytes response and thus, it is cleared by the host. This is referred to as acute LCMV infection. On the other hand, Clone 13 is a variant of the Armstrong viral strain, isolated from the spleen and is tropic for visceral organs, it was first isolated from mice. This variant potentiates a less vigorous CTL response in the immune system, thus can persist in the host organism indefinitely; the latter is referred to as chronic LCMV infection. LCMV is a spherical enveloped virus with a diameter between 300 nm.

The helical nucleocapsid contains an RNA genome consisting of two negative single-stranded RNA segments. The negative RNA strand, complementary to the necessary mRNA strand, indicates that it must first be transcribed into a positive mRNA strand before it can be translated into the required proteins; the L strand is ambisense RNA, encoding multiple proteins in opposite directions, separated by an intergenic region. It is 7.2 kb in size and encodes a high-molecular-mass protein and an 11 kDa small polypeptide Z with unknown function and a ring finger motif. The viral RNA-dependent RNA polymerase is encoded by the L protein which contains conserved characteristic motifs throughout all the RNA-dependent, RNA-polymerases; the S strand is ambisense and 3.4 kb in size. It encodes the two main structural proteins: nucleo-protein and glycoprotein C; the latter undergoes posttranslational cleavage and results in the synthesis of two mature virion glycoproteins, GP-1 and GP-2. The spikes present on the virion envelope are dictated by tetramer formation of GP-1 and GP-2.

When LCMV attacks a cell, the process of replication starts by attachment of the virus to host receptors through its surface glycoproteins. It is endocytosed into a vesicle inside the host cell and creates a fusion of the virus and vesicle membranes; the ribonucleocapsid is released in the cytoplasm. The RNA-dependent, RNA-polymerase brought along with the virus binds to a promoter on the L and S segments and begins transcription from negative-stranded to a positive-stranded mRNA; the formation of a strong hairpin sequence at the end of each gene terminates transcription. The mRNA strands are capped by the RNA-dependent, RNA-polymerase in the cytoplasm and are subsequently translated into the four proteins essential for LCMV assembly; the ribonucleocapsid interacts with the Z matrix protein and buds on the cell membrane, releasing the virion out from the infected cell. The first arenavirus, Lymphocytic choriomeningitis mammarenavirus, was isolated in 1933 by Charles Armstrong during a study of an epidemic in St. Louis.

Although not the cause of the outbreak, LCMV was found to be a cause of nonbacterial or aseptic meningitis. In 1996, Peter Doherty and Rolf Zinkernagel shared the Nobel Prize in Medicine and Physiology, for their work

Gul Circle MRT station is an above-ground Mass Rapid Transit station along the East West Line located at the boundary of the planning areas of Tuas and Pioneer, Singapore. Gul Circle station is the only above-ground station on the MRT network where the eastbound and westbound platforms are not located on the same level; the idea of the extension was first mooted on 25 January 2008 with the extension proposed to be completed by 2015. The stations were first announced on 11 January 2011 by Transport Minister Mr Raymond Lim in a speech while visiting Bedok when new platform screen doors opened there and fixed 2016 as the original year of the line completion; the station is expected to benefit an estimated 100,000 commuters daily. It is the first elevated stacked island platform, as there is a possible future two-station extension to Tuas South leading out from this station or interchange with another line; the $190-million contract was awarded to Shanghai Tunnel Engineering, a major civil engineering company from China for this station.

This station ceiling is 33 metres above ground - about the height of a 10-storey HDB block, the highest elevated station along the MRT network. There are two reasons for the height. Firstly, the 7.5 km, $3.5 billion extension goes over the Ayer Rajah Expressway viaduct at the Pan-Island Expressway interchange. Secondly, a 4.8 km portion of the line is integrated with a road viaduct, which runs below the rail line. The opening of the station was delayed from 2016 to the second quarter of 2017 to make way for the installation of the new signalling system, it became operational on 18 June that year. Train services between Gul Circle and Tuas Link were temporary closed between 16 and 19 November 2017 following a collision that happened at Joo Koon. On 20 November 2017, train services from Gul Circle to Tuas Link were resumed. During the suspension, train services are as follows, with the exception of Sunday signalling trials which have commenced on 29 April 2018: From 28 May 2018 onwards, trains once again ran through from Pasir Ris to Tuas Link and vice versa, after the transition to the CBTC Moving Block system, passengers will no longer need to alight at Gul Circle.

Platform A, located at L3 is for trains heading to Pasir Ris Platform B, located at L4 is for trains heading to Tuas Link. The station was built with two extra tracks opposite the operational EWL tracks, for cross-platform interchange with a future two-station extension of the line to Tuas South. However, on 7 March 2019, the Government announced that Tuas South did not have enough ridership in the near to medium term to support an MRT line. Official website

Bethesda Episcopal Church is an Episcopal Church in Saratoga Springs, New York. The parish was incorporated in 1830. In 1841 it purchased the site of its present church at 41 Washington Street. Architect Richard Upjohn drew up plans for the church in English Gothic style, construction was begun in 1842; the first services were held in the building in 1844. Side aisles were added in 1856. In 1886 Mrs. Rockwell Putnam, widow of the owner of the Grand Union Hotel in Saratoga Springs, donated money for construction of a tower in memory of her late husband. Architect A. Page Brown designed the additions in Norman Romanesque style; the work was completed in 1887. A notable feature of the renovation was the addition of Tiffany windows in the front facade; the church is listed in the National Register of Historic Places as a contributing property of the Broadway Historic District in Saratoga Springs. National Register of Historic Places listings in Saratoga County, New York Official website